Difference between revisions of "Polycythemia vera"
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− | ''There were several doses evaluated in Verstovsek et al. 2014; the median total daily dose was 21.7 mg corresponding to approximately 10 mg PO twice per day. The most common comparator in RESPONSE was hydroxyurea, followed by interferon and anagrelide.'' | + | ''There were several doses evaluated in Verstovsek et al. 2014; the median total daily dose was 21.7 mg corresponding to approximately 10 mg PO twice per day. The most common comparator in RESPONSE was [[Polycythemia_vera#Hydroxyurea_.28Hydrea.29|hydroxyurea]], followed by interferon and [[Polycythemia_vera#Anagrelide_.28Agrylin.29|anagrelide]].'' |
*[[Ruxolitinib (Jakafi)]] 10 mg PO twice per day | *[[Ruxolitinib (Jakafi)]] 10 mg PO twice per day |
Revision as of 01:38, 21 February 2015
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10 regimens on this page
11 variants on this page
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Relapsed, refractory, or intolerant
Anagrelide (Agrylin)
Regimen
Study | Evidence | Comparator | Efficacy |
Vannucchi et al. 2015 (RESPONSE) | Phase III | Ruxolitinib | Decreased disease control |
To be completed
References
- Vannucchi AM, Kiladjian JJ, Griesshammer M, Masszi T, Durrant S, Passamonti F, Harrison CN, Pane F, Zachee P, Mesa R, He S, Jones MM, Garrett W, Li J, Pirron U, Habr D, Verstovsek S. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015 Jan 29;372(5):426-35. link to original article contains verified protocol PubMed
Hydroxyurea (Hydrea)
Regimen
Study | Evidence | Comparator | Efficacy |
Vannucchi et al. 2015 (RESPONSE) | Phase III | Ruxolitinib | Decreased disease control |
To be completed
References
- Vannucchi AM, Kiladjian JJ, Griesshammer M, Masszi T, Durrant S, Passamonti F, Harrison CN, Pane F, Zachee P, Mesa R, He S, Jones MM, Garrett W, Li J, Pirron U, Habr D, Verstovsek S. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015 Jan 29;372(5):426-35. link to original article contains verified protocol PubMed
Ruxolitinib (Jakafi)
back to top |
Regimen
Study | Evidence | Comparator | Efficacy |
Verstovsek et al. 2014 | Phase II | N/A | N/A |
Vannucchi et al. 2015 (RESPONSE) | Phase III | Standard therapy | Increased disease control |
There were several doses evaluated in Verstovsek et al. 2014; the median total daily dose was 21.7 mg corresponding to approximately 10 mg PO twice per day. The most common comparator in RESPONSE was hydroxyurea, followed by interferon and anagrelide.
- Ruxolitinib (Jakafi) 10 mg PO twice per day
Continued until progression or excess toxicity
References
- Verstovsek S, Passamonti F, Rambaldi A, Barosi G, Rosen PJ, Rumi E, Gattoni E, Pieri L, Guglielmelli P, Elena C, He S, Contel N, Mookerjee B, Sandor V, Cazzola M, Kantarjian HM, Barbui T, Vannucchi AM. A phase 2 study of ruxolitinib, an oral JAK1 and JAK2 Inhibitor, in patients with advanced polycythemia vera who are refractory or intolerant to hydroxyurea. Cancer. 2014 Feb 15;120(4):513-20. link to original article contains verified protocol PubMed content property of HemOnc.org
- Vannucchi AM, Kiladjian JJ, Griesshammer M, Masszi T, Durrant S, Passamonti F, Harrison CN, Pane F, Zachee P, Mesa R, He S, Jones MM, Garrett W, Li J, Pirron U, Habr D, Verstovsek S. Ruxolitinib versus standard therapy for the treatment of polycythemia vera. N Engl J Med. 2015 Jan 29;372(5):426-35. link to original article contains verified protocol PubMed