Difference between revisions of "Borofalan-10B (Steboronine)"
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(Created page with "==Mechanism of action== From the [https://www.cancer.gov/publications/dictionaries/cancer-drug/def/borofalan-10b NCI Drug Dictionary]]: A boronated phenylalanine and boron (bo...") |
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Latest revision as of 17:34, 8 June 2023
Mechanism of action
From the NCI Drug Dictionary]: A boronated phenylalanine and boron (boron-10) carrier that may be used in boron neutron capture therapy (BNCT), with potential antineoplastic activity. Upon administration, borofalan (10B) is absorbed mostly by tumor cells. When exposed to neutron irradiation, borofalan (10B) absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells spares adjacent normal tissues.
Diseases for which is used
History of changes in PMDA indication
- 2020-03-25: Newly indicated for the treatment of locally unresectable recurrent or unresectable advanced head and neck cancer.
Also known as
- Code name: SPM-011
- Brand name: Borofalan