Difference between revisions of "Thrombocytopenia and platelet dysfunction"
Jump to navigation
Jump to search
m (→"How I Treat") |
Warner-admin (talk | contribs) m (Text replacement - "[[Thrombotic th" to "[[Acquired thrombotic th") |
||
| Line 18: | Line 18: | ||
*Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | *Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | ||
*[[Peripheral smear findings|Peripheral smear]], platelet clumps | *[[Peripheral smear findings|Peripheral smear]], platelet clumps | ||
| − | *Clinical history (bleeding, temporality, recent infections), [[ | + | *Clinical history (bleeding, temporality, recent infections), [[Acquired thrombotic thrombocytopenic purpura|TTP]]/[[Atypical hemolytic uremic syndrome|aHUS]] |
*Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | *Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | ||
*Lifestyle factors (e.g. alcohol) | *Lifestyle factors (e.g. alcohol) | ||
| Line 35: | Line 35: | ||
*[[Heparin-induced thrombocytopenia (HIT)]] | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
*[[Thrombocytopenia in liver disease]] | *[[Thrombocytopenia in liver disease]] | ||
| − | *[[ | + | *[[Acquired thrombotic thrombocytopenic purpura]] |
[[Category:Hematology reference pages]] | [[Category:Hematology reference pages]] | ||
Revision as of 13:19, 7 June 2023
Guidelines
"How I Treat"
- 2023: Stanworth & Mumford How I diagnose and treat neonatal thrombocytopenia PubMed
- 2022: Stanworth & Shah How I use platelet transfusions PubMed
- 2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
- 2021: Kyrle & Eichinger How I manage cyclic thrombocytopenia
Definition of thrombocytopenia
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP