Difference between revisions of "Malignant solid neoplasm, RET-mutated"
Jump to navigation
Jump to search
Warner-admin (talk | contribs) m (Text replacement - " (NCT[0-9]{8})" to " https://clinicaltrials.gov/ct2/show/$1") |
|||
| Line 34: | Line 34: | ||
</div></div> | </div></div> | ||
===References=== | ===References=== | ||
| − | # '''LIBRETTO-001:''' Subbiah V, Wolf J, Konda B, Kang H, Spira A, Weiss J, Takeda M, Ohe Y, Khan S, Ohashi K, Soldatenkova V, Szymczak S, Sullivan L, Wright J, Drilon A. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial. Lancet Oncol. 2022 Oct;23(10):1261-1273. Epub 2022 Sep 12. [https://doi.org/10.1016/s1470-2045(22)00541-1 link to original article] [https://pubmed.ncbi.nlm.nih.gov/36108661/ PubMed] NCT03157128 | + | # '''LIBRETTO-001:''' Subbiah V, Wolf J, Konda B, Kang H, Spira A, Weiss J, Takeda M, Ohe Y, Khan S, Ohashi K, Soldatenkova V, Szymczak S, Sullivan L, Wright J, Drilon A. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial. Lancet Oncol. 2022 Oct;23(10):1261-1273. Epub 2022 Sep 12. [https://doi.org/10.1016/s1470-2045(22)00541-1 link to original article] [https://pubmed.ncbi.nlm.nih.gov/36108661/ PubMed] https://clinicaltrials.gov/ct2/show/NCT03157128 |
[[Category:RET regimens]] | [[Category:RET regimens]] | ||
[[Category:Biomarker-specific pages]] | [[Category:Biomarker-specific pages]] | ||
[[Category:Malignant solid neoplasm]] | [[Category:Malignant solid neoplasm]] | ||
[[Category:Site-agnostic regimens]] | [[Category:Site-agnostic regimens]] | ||
Revision as of 12:59, 6 June 2023
1 regimens on this page
1 variants on this page
|
Advanced or metastatic disease, all lines of therapy
Selpercatinib monotherapy
Regimen
| Study | Dates of enrollment | Evidence | |
|---|---|---|---|
Subbiah et al. 2022 (LIBRETTO-001)
|
2017-12-04 to 2021-08-04 | Phase 1/2 (RT) |
Note: this is the phase 2 recommended dosing.
References
- LIBRETTO-001: Subbiah V, Wolf J, Konda B, Kang H, Spira A, Weiss J, Takeda M, Ohe Y, Khan S, Ohashi K, Soldatenkova V, Szymczak S, Sullivan L, Wright J, Drilon A. Tumour-agnostic efficacy and safety of selpercatinib in patients with RET fusion-positive solid tumours other than lung or thyroid tumours (LIBRETTO-001): a phase 1/2, open-label, basket trial. Lancet Oncol. 2022 Oct;23(10):1261-1273. Epub 2022 Sep 12. link to original article PubMed https://clinicaltrials.gov/ct2/show/NCT03157128