Warfarin (Coumadin)

General information

Class/mechanism: Vitamin K antagonist, inhibits the production of several vitamin K-dependent clotting factors, such as factor II (prothrombin), factor VII (proconvertin), factor IX (plasma thromboplastin component), factor X (Stuart factor), protein C, and protein S. Warfarin interferes with regeneration of vitamin K1 epoxide by inhibiting the C1 subunit of vitamin K epoxide reductase (VKORC1). Some nucleotide polymorphisms in VKOR and CYP2C9 variants have been associated with different warfarin dose requirements.
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Patient drug information

• Warfarin (Coumadin) package insert
• Warfarin (Coumadin) patient drug information (UpToDate)

Diseases for which it is used

• Antiphospholipid antibody syndrome
• Venous thromboembolism

Also known as

• Generic name: warfarina sodica
• Brand names:

Synonyms
Aldocumar	Anasmol	Anticoag	Arefarin	Athrombin-K	Befarin	Caumadin	Cicoxil
Circuvit	Coumadin	Coumadine	Couparin	Dagonal	Farin	Ferevan	Fericard
Haemofarin	Jantoven	Kovar	Lawarin	Maforan	Marfarin	Marivanil	Marivarin
Orfarin	Panwarfin	Panwarfine	Romesa	Samofaron	Simarc	Tedicumar	Varfarins
Varfine	Waran	Warf	Warfa	Warfant	Warfar	Warfarex	Warfil
Warfilone	Warfin	Warin	Warlin	Warnerin	Werifrin