Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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==="How I Treat"=== | ==="How I Treat"=== | ||
*'''2022:''' Stanworth & Shah [https://doi.org/10.1182/blood.2022016558 How I use platelet transfusions] | *'''2022:''' Stanworth & Shah [https://doi.org/10.1182/blood.2022016558 How I use platelet transfusions] | ||
| + | *'''2022:''' Fiore et al. [https://doi.org/10.1182/blood.2021011595 How I manage pregnancy in women with Glanzmann thrombasthenia] | ||
*'''2021:''' Kyrle & Eichinger [https://doi.org/10.1182/blood.2020008218 How I manage cyclic thrombocytopenia] | *'''2021:''' Kyrle & Eichinger [https://doi.org/10.1182/blood.2020008218 How I manage cyclic thrombocytopenia] | ||
| − | ==Definition== | + | ==Definition of thrombocytopenia== |
Platelet count less than 150 × 10<sup>9</sup>/L or less than the lower limit of normal as defined by a local laboratory. | Platelet count less than 150 × 10<sup>9</sup>/L or less than the lower limit of normal as defined by a local laboratory. | ||
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==Relevant diagnoses== | ==Relevant diagnoses== | ||
*[[Atypical hemolytic uremic syndrome]] | *[[Atypical hemolytic uremic syndrome]] | ||
| + | *[[Glanzmann thrombasthenia]] | ||
*[[Immune thrombocytopenia (ITP)]] | *[[Immune thrombocytopenia (ITP)]] | ||
*[[Heparin-induced thrombocytopenia (HIT)]] | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
Revision as of 20:16, 5 April 2023
Guidelines
"How I Treat"
- 2022: Stanworth & Shah How I use platelet transfusions
- 2022: Fiore et al. How I manage pregnancy in women with Glanzmann thrombasthenia
- 2021: Kyrle & Eichinger How I manage cyclic thrombocytopenia
Definition of thrombocytopenia
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP