Difference between revisions of "Tenosynovial giant cell tumor"
Jump to navigation
Jump to search
Warner-admin (talk | contribs) m (Text replacement - "'''contains verified protocol'''" to "'''contains dosing details in manuscript'''") |
m |
||
| Line 13: | Line 13: | ||
=All lines of therapy= | =All lines of therapy= | ||
==Pexidartinib monotherapy {{#subobject:a9367b|Regimen=1}}== | ==Pexidartinib monotherapy {{#subobject:a9367b|Regimen=1}}== | ||
| − | + | <div class="toccolours" style="background-color:#eeeeee"> | |
===Regimen {{#subobject:43c238|Variant=1}}=== | ===Regimen {{#subobject:43c238|Variant=1}}=== | ||
{| class="wikitable sortable" style="width: 100%; text-align:center;" | {| class="wikitable sortable" style="width: 100%; text-align:center;" | ||
| Line 30: | Line 30: | ||
|} | |} | ||
''<sup>1</sup>Patents assigned to placebo were offered open-label pexidartinib after week 24.'' | ''<sup>1</sup>Patents assigned to placebo were offered open-label pexidartinib after week 24.'' | ||
| + | <div class="toccolours" style="background-color:#b3e2cd"> | ||
====Targeted therapy==== | ====Targeted therapy==== | ||
*[[Pexidartinib (Turalio)]] as follows: | *[[Pexidartinib (Turalio)]] as follows: | ||
**Cycle 1: 400 mg PO every morning and 600 mg PO every evening | **Cycle 1: 400 mg PO every morning and 600 mg PO every evening | ||
**Cycle 2 onwards: 400 mg PO twice per day | **Cycle 2 onwards: 400 mg PO twice per day | ||
| − | |||
'''14-day cycles''' | '''14-day cycles''' | ||
| − | + | </div></div> | |
===References=== | ===References=== | ||
# '''ENLIVEN:''' Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators. Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet. 2019 Aug 10;394(10197):478-487. Epub 2019 Jun 19. [https://doi.org/10.1016/s0140-6736(19)30764-0 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6860022/ link to PMC article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/31229240/ PubMed] NCT02371369 | # '''ENLIVEN:''' Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators. Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet. 2019 Aug 10;394(10197):478-487. Epub 2019 Jun 19. [https://doi.org/10.1016/s0140-6736(19)30764-0 link to original article] [https://www.ncbi.nlm.nih.gov/pmc/articles/pmc6860022/ link to PMC article] '''contains dosing details in manuscript''' [https://pubmed.ncbi.nlm.nih.gov/31229240/ PubMed] NCT02371369 | ||
| − | |||
[[Category:Tenosynovial giant cell tumor regimens]] | [[Category:Tenosynovial giant cell tumor regimens]] | ||
[[Category:Disease-specific pages]] | [[Category:Disease-specific pages]] | ||
[[Category:Soft tissue sarcomas]] | [[Category:Soft tissue sarcomas]] | ||
Revision as of 23:46, 28 February 2023
Section editor transclusions Note: these are regimens tested in subtype-specific populations, please see the main soft tissue sarcoma page for other regimens.
1 regimens on this page
1 variants on this page
|
All lines of therapy
Pexidartinib monotherapy
Regimen
| Study | Years of enrollment | Evidence | Comparator | Comparative Efficacy |
|---|---|---|---|---|
| Tap et al. 2019 (ENLIVEN) | 2015-2016 | Phase 3 (E-RT-esc) | Placebo1 | Superior ORR |
1Patents assigned to placebo were offered open-label pexidartinib after week 24.
Targeted therapy
- Pexidartinib (Turalio) as follows:
- Cycle 1: 400 mg PO every morning and 600 mg PO every evening
- Cycle 2 onwards: 400 mg PO twice per day
14-day cycles
References
- ENLIVEN: Tap WD, Gelderblom H, Palmerini E, Desai J, Bauer S, Blay JY, Alcindor T, Ganjoo K, Martín-Broto J, Ryan CW, Thomas DM, Peterfy C, Healey JH, van de Sande M, Gelhorn HL, Shuster DE, Wang Q, Yver A, Hsu HH, Lin PS, Tong-Starksen S, Stacchiotti S, Wagner AJ; ENLIVEN investigators. Pexidartinib versus placebo for advanced tenosynovial giant cell tumour (ENLIVEN): a randomised phase 3 trial. Lancet. 2019 Aug 10;394(10197):478-487. Epub 2019 Jun 19. link to original article link to PMC article contains dosing details in manuscript PubMed NCT02371369