Difference between revisions of "Vadimezan (AS-A404)"
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Revision as of 00:38, 3 December 2022
Mechanism of action
From the NCI Drug Dictionary: A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages.