Difference between revisions of "Docetaxel (Taxotere)"
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(Created page with "==General information== Class/mechanism: <ref name="insert">[http://products.sanofi.us/taxotere/taxotere.pdf Docetaxel (Taxotere) package insert]</ref><ref>[http://hemonc.org/doc...") |
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==General information== | ==General information== | ||
| − | Class/mechanism: <ref name="insert">[http://products.sanofi.us/taxotere/taxotere.pdf Docetaxel (Taxotere) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/docetaxel.pdf Docetaxel (Taxotere) package insert (locally hosted backup)]</ref> | + | Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.<ref name="insert">[http://products.sanofi.us/taxotere/taxotere.pdf Docetaxel (Taxotere) package insert]</ref><ref>[http://hemonc.org/docs/packageinsert/docetaxel.pdf Docetaxel (Taxotere) package insert (locally hosted backup)]</ref> |
| − | <br>Route: | + | <br>Route: IV |
| − | <br>Extravasation: | + | <br>Extravasation: [[irritant]], rare [[vesicant]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the package insert<ref name="insert"></ref>. | ||
Revision as of 15:59, 24 December 2011
General information
Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert[1].
Patient drug information
- Docetaxel (Taxotere) patient drug information (Chemocare)[3]
- Docetaxel (Taxotere) patient drug information (UpToDate)[4]