Difference between revisions of "Ondansetron (Zofran)"
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==References== | ==References== | ||
− | * Italian Group for Antiemetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med. 2000 May 25;342(21):1554-9. [https:// | + | * Italian Group for Antiemetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med. 2000 May 25;342(21):1554-9. [https://doi.org/10.1056/NEJM200005253422102 link to original article] [https://pubmed.ncbi.nlm.nih.gov/10824073 PubMed] |
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Revision as of 14:12, 15 September 2022
General information
Class/mechanism: Selective serotonin 5-HT3 receptor antagonist. Chemotherapy medications can cause nausea and vomiting by stimulating release of serotonin from the enterochromaffin cells of the small intestine, and serotonin triggers the vomiting reflex by binding to and activating 5-HT3 receptors. Ondansetron prevents nausea and vomiting by binding with high affinity to 5-HT3 receptors and blocking their activation by serotonin.[1][2]
Route: PO, IV
Extravasation: no information available
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Patient drug information
- Patient counseling information can be found in the Ondansetron (Zofran) package insert[1]
- Ondansetron (Zofran) patient drug information (UpToDate)[3]
History of changes in FDA indication
- 1/4/1991: Initial FDA approval
Also known as
- Code name: SN-307
- Brand names:
Synonyms | |||||||
---|---|---|---|---|---|---|---|
Alencar | Amilene | Ansentron | Anset | Atossa | Bryterol | Cedantron | Ceramos |
Danofran | Dantenk | Emeran | Emeset | Emetra | Emetron | Emigo | Emistat |
Emivox | Espasevit | Finaber | Finoxi | Frazon | Glendan | Helmine | Injectrax |
Insetron | Invomit | Izofran | Latran | Modifical | Narfoz | Nausedron | Nautah |
Neomit | Nuset | O.N.D. | Odanex | Odanse | Ometic | Omstron | Onaset |
Oncotor | Onda | Ondace | Ondan | Ondanles | Ondansetron-Z | Ondant | Ondaren |
Ondasetron | Ondatie | Ondavell | Ondem | Ondemet | Onfran | Onilat | Onsat |
Onseran | Onset | Onsetron | Onsett | Onsia | Ontrax | Onzod | Osetron |
Ostasyn | Otobrol | Periset | Quimiofran | Seton | Setronax | Setronon | Sopran |
Trorix | Vomceran | Vomiban | Vomigo | Vomikind | Vomiset | Vomitron | Vomiz |
Vonau | Yatrox | Zantron | Zapron | Zemitron | Zofer | Zofran | Zofran ODT |
Zofron | Zoltem | Zonax | Zondan | Zophren | Zudan | Zuplenz |
References
- Italian Group for Antiemetic Research. Dexamethasone alone or in combination with ondansetron for the prevention of delayed nausea and vomiting induced by chemotherapy. N Engl J Med. 2000 May 25;342(21):1554-9. link to original article PubMed