Difference between revisions of "Bendamustine"
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*[[Multiple myeloma]] | *[[Multiple myeloma]] | ||
*[[T-cell lymphoma]] | *[[T-cell lymphoma]] | ||
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*[[Waldenström macroglobulinemia]] | *[[Waldenström macroglobulinemia]] | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
+ | [[Category:Intravenous chemotherapy]] | ||
[[Category:Vesicant chemotherapy]] | [[Category:Vesicant chemotherapy]] | ||
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[[Category:Nitrogen mustards]] | [[Category:Nitrogen mustards]] | ||
[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
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[[Category:Multiple myeloma medications]] | [[Category:Multiple myeloma medications]] | ||
[[Category:T-cell lymphoma medications]] | [[Category:T-cell lymphoma medications]] | ||
+ | [[Category:Transplant medications]] | ||
[[Category:Waldenström macroglobulinemia medications]] | [[Category:Waldenström macroglobulinemia medications]] | ||
[[Category:Drugs FDA approved in 2008]] | [[Category:Drugs FDA approved in 2008]] |
Revision as of 00:29, 14 November 2014
General information
Class/mechanism: Nitrogen mustard, alkylator; bifunctional mechlorethamine derivative containing a purine-like benzimidazole ring which forms electrophilic alkyl groups, resulting in interstrand DNA crosslinks, leading to cell death via several pathways in both quiescent and dividing cells.[1][2][3]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Aggressive Non-Hodgkin lymphoma
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Follicular lymphoma
- Hairy cell leukemia
- Hodgkin lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma
- Multiple myeloma
- T-cell lymphoma
- Transplant conditioning regimens
- Waldenström macroglobulinemia
Patient drug information
- Bendamustine (Treanda) patient drug information (Chemocare)[4]
- Brief patient counseling information can be found on page 7 of the package insert[1]
- Bendamustine (Treanda) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 3/20/2008: Initial FDA approval "for the treatment of patients with chronic lymphocytic leukemia (CLL)."
- 4/22/2009: Additional indication for "Indolent B-cell non-Hodgkin’s lymphoma (NHL) that has progressed during or within six months of treatment with rituximab or a rituximab containing regimen."
Also known as
Bendamustine Hydrochloride, Ribomustin, SDX-105, or Treakisym.
References
- Drug index
- Chemotherapy
- Intravenous chemotherapy
- Vesicant chemotherapy
- Nitrogen mustards
- Alkylating agents
- Aggressive Non-Hodgkin lymphoma medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Follicular lymphoma medications
- Hairy cell leukemia medications
- Hodgkin lymphoma medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Multiple myeloma medications
- T-cell lymphoma medications
- Transplant medications
- Waldenström macroglobulinemia medications
- Drugs FDA approved in 2008