Difference between revisions of "Interferon alfa-2a (Roferon-A)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| − | ==Diseases for which it is | + | ==Diseases for which it is established== |
*[[Chronic myelogenous leukemia]] | *[[Chronic myelogenous leukemia]] | ||
*[[Hairy cell leukemia]] | *[[Hairy cell leukemia]] | ||
| + | *[[Renal cell carcinoma]] | ||
| + | |||
| + | ==Diseases for which it is used== | ||
*[[Kaposi sarcoma]] | *[[Kaposi sarcoma]] | ||
*[[Neuroendocrine tumor]] | *[[Neuroendocrine tumor]] | ||
| − | |||
*[[Cutaneous squamous cell carcinoma]] | *[[Cutaneous squamous cell carcinoma]] | ||
Revision as of 12:24, 19 May 2022
General information
Class/mechanism: Immune system activator; binds to human type 1 interferon, activating downstream intracellular signal transduction pathways initially mediated by the JAK/STAT pathway. Interferon α-2a activates multiple biologic effects which are not fully understood.[1][2]
Route: SC
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is established
Diseases for which it is used
Diseases for which it was used
Patient drug information
- Interferon alfa-2a (Roferon-A) package insert[1]
- Interferon alfa-2a (Roferon-A) patient drug information (Chemocare)[3]
History of changes in FDA indication
- 6/4/1986: Initial FDA approval for treatment of patients 18 years of age or older with hairy cell leukemia
- Uncertain date: In addition, it is indicated for chronic phase, Philadelphia chromosome (Ph) positive chronic myelogenous leukemia (CML) patients who are minimally pretreated (within 1 year of diagnosis).
Also known as
- Brand name: Laroferon, Roferon-A
References
- Drugs
- Subcutaneous medications
- Interferon alfa
- Chronic myelogenous leukemia medications
- Hairy cell leukemia medications
- Kaposi sarcoma medications
- Neuroendocrine tumor medications
- Renal cell carcinoma medications
- Cutaneous squamous cell carcinoma medications
- Follicular lymphoma medications (historic)
- Melanoma medications (historic)
- Multiple myeloma medications (historic)
- FDA approved in 1986