Difference between revisions of "Vinorelbine (Navelbine)"
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*[[Cervical cancer]] | *[[Cervical cancer]] | ||
*[[Diffuse large B-cell lymphoma]] | *[[Diffuse large B-cell lymphoma]] | ||
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*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
*[[Malignant pleural mesothelioma]] | *[[Malignant pleural mesothelioma]] | ||
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[[Category:Cervical cancer medications]] | [[Category:Cervical cancer medications]] | ||
[[Category:Diffuse large B-cell lymphoma medications]] | [[Category:Diffuse large B-cell lymphoma medications]] | ||
+ | [[Category:Esophageal cancer medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
[[Category:Malignant pleural mesothelioma medications]] | [[Category:Malignant pleural mesothelioma medications]] |
Revision as of 01:17, 19 May 2022
General information
Class/mechanism: Vinca alkaloid, inhibits microtubule formation in the mitotic spindle, causing cell cycle arrest in metaphase. Vinorelbine may possibly also disrupt: amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent calcium transport ATPase activity; and DNA/RNA and lipid synthesis.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Disease for which it is used
- Breast cancer
- Cervical cancer
- Diffuse large B-cell lymphoma
- Esophageal cancer
- Hodgkin lymphoma
- Malignant pleural mesothelioma
- Non-small cell lung cancer
- Ovarian cancer
- Soft tissue sarcoma
- Small cell lung cancer
Patient drug information
- Vinorelbine (Navelbine) patient drug information (Chemocare)[3]
- Vinorelbine (Navelbine) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 12/23/1994: Initial FDA approval as a single agent or in combination with cisplatin for the first-line treatment of ambulatory patients with unresectable, advanced non-small cell lung cancer (NSCLC)
Also known as
- Code name: KW-2307
- Generic name: NVB, vinorelbine tartrate
- Brand names: Binorel, Biovelbin, Eunades, Flonorbin, Navelbine, Neoben, Relbovin, Vinelbine, Vinorelbel, Vinotec
References
- Drugs
- Intravenous medications
- Vesicant
- Microtubule inhibitors
- Vinca alkaloids
- Breast cancer medications
- Cervical cancer medications
- Diffuse large B-cell lymphoma medications
- Esophageal cancer medications
- Hodgkin lymphoma medications
- Malignant pleural mesothelioma medications
- Non-small cell lung cancer medications
- Non-small cell lung cancer, nonsquamous medications
- Ovarian cancer medications
- Soft tissue sarcoma medications
- Small cell lung cancer medications
- FDA approved in 1994
- WHO Essential Cancer Medicine