Difference between revisions of "Methotrexate (MTX)"
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==Also known as== | ==Also known as== | ||
Abitrexate, Alltrex, Amethopterin, Antifolan, APO-Methotrexate, Artrait, Biometrox, Biotrexate, Caditrex, Cytotrexate, Ebetrexat, Emthexat, Emthexate, Emthexate PF, Emthexate S, Ervemin, Farmitrexat, Fauldmetro, Folex PFS, Folitrax, Hextrate, Ifamet, Imutrex,Ledertrexate, Ledertrexate Sodium, Ledertrexato, Lumexon, Matrex, Maxtrex, Medsatrexate, Merex, Metex, Methobax, Methoblastin, Methorex, Methotrexaat, Methotrexaat Sandoz, Methotrexat Biosyn, Methotrexat Ebewe, Methotrexate Bigmar, Methotrexate Bristol, Methotrexate DBL, Methotrexate Disodium, Methotrexate DUP, Methotrexate Ebewe, Methotrexate Farmos, Methotrexate Knoll, Methotrexate Lederle, Methotrexate LPF, Methotrexate Mayne, Methotrexate Merck, Methotrexate Paranova, Methotrexate R, Methotrexate Remedica, Methotrexate Singad, Methotrexate Sodium, Methotrexate Sodium Lederle, Methotrexate Teva, Methotrexate Wyeth, Methotrexat Lederle, Methotrexat Medac, Methotrexato, Methotrexat Ridupharm, Methotrexat Teva, Methotrexatum, Meticil, Metolate, Metotressato, Metotrexate, Metotrexato Asofarma, Metotrexato Chiesi, Metotrexato Dosa, Metotrexato Filaxis, Metotrexato Lederle, Metotrexato Martian, Metotrexato Microsules, Metotrexol, Metrex, Metrexan, Metrexato, Metrotex, Mexate, Miantrex CS, MTX, MTX Hexal, Neometho, Neotrexate, Novatrex, Oncotrex, Oncotrex-PF, O Trexat, P&U Methotrexate, Pharmatrexate, Ratio-Methotrexate, Remtrex, Reumatrex, Rextop, Rheumatrex, Tecnomet, Texate, Texate T, Texorate, Tratoben, Trav Methotrexate, Tremetex, Trexall, Trexan, Trexeron, Trixilem, Trixilem RU, Unitrexate, Vero Methotrexate, Zexate | Abitrexate, Alltrex, Amethopterin, Antifolan, APO-Methotrexate, Artrait, Biometrox, Biotrexate, Caditrex, Cytotrexate, Ebetrexat, Emthexat, Emthexate, Emthexate PF, Emthexate S, Ervemin, Farmitrexat, Fauldmetro, Folex PFS, Folitrax, Hextrate, Ifamet, Imutrex,Ledertrexate, Ledertrexate Sodium, Ledertrexato, Lumexon, Matrex, Maxtrex, Medsatrexate, Merex, Metex, Methobax, Methoblastin, Methorex, Methotrexaat, Methotrexaat Sandoz, Methotrexat Biosyn, Methotrexat Ebewe, Methotrexate Bigmar, Methotrexate Bristol, Methotrexate DBL, Methotrexate Disodium, Methotrexate DUP, Methotrexate Ebewe, Methotrexate Farmos, Methotrexate Knoll, Methotrexate Lederle, Methotrexate LPF, Methotrexate Mayne, Methotrexate Merck, Methotrexate Paranova, Methotrexate R, Methotrexate Remedica, Methotrexate Singad, Methotrexate Sodium, Methotrexate Sodium Lederle, Methotrexate Teva, Methotrexate Wyeth, Methotrexat Lederle, Methotrexat Medac, Methotrexato, Methotrexat Ridupharm, Methotrexat Teva, Methotrexatum, Meticil, Metolate, Metotressato, Metotrexate, Metotrexato Asofarma, Metotrexato Chiesi, Metotrexato Dosa, Metotrexato Filaxis, Metotrexato Lederle, Metotrexato Martian, Metotrexato Microsules, Metotrexol, Metrex, Metrexan, Metrexato, Metrotex, Mexate, Miantrex CS, MTX, MTX Hexal, Neometho, Neotrexate, Novatrex, Oncotrex, Oncotrex-PF, O Trexat, P&U Methotrexate, Pharmatrexate, Ratio-Methotrexate, Remtrex, Reumatrex, Rextop, Rheumatrex, Tecnomet, Texate, Texate T, Texorate, Tratoben, Trav Methotrexate, Tremetex, Trexall, Trexan, Trexeron, Trixilem, Trixilem RU, Unitrexate, Vero Methotrexate, Zexate | ||
+ | |||
+ | ==History of changes in FDA indication== | ||
+ | * 12/7/1953: Initial FDA approval | ||
==References== | ==References== | ||
<references/> | <references/> | ||
+ | [[Category:Drug index]] | ||
+ | [[Category:Chemotherapy]] | ||
[[Category:Antimetabolites]] | [[Category:Antimetabolites]] | ||
[[Category:Antifolates]] | [[Category:Antifolates]] | ||
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[[Category:T-cell lymphoma medications]] | [[Category:T-cell lymphoma medications]] | ||
[[Category:Transplant medications]] | [[Category:Transplant medications]] | ||
+ | |||
+ | [[Category:Drugs FDA approved in 1953]] |
Revision as of 14:17, 3 November 2014
General information
Class/mechanism: Folate analog, antimetabolite, interferes with DNA synthesis. Methotrexate inhibits dihydrofolic acid reductase, which catalyzes reactions that produce tetrahydrofolates, which are used in purine nucleotide and thymidylate synthesis.[1][2]
Route: IV, PO, IM, IT, intraarterial
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Acute promyelocytic leukemia
- Aggressive Non-Hodgkin lymphoma
- Bladder cancer
- Bone cancer
- Breast cancer
- CNS lymphoma
- Head and neck cancer
- HIV-associated lymphoma
- Mantle cell lymphoma
- Penile cancer
- Prostate cancer
- Small cell lung cancer
- T-cell lymphoma
- Transplant conditioning regimens
Patient drug information
- Methotrexate (MTX) patient drug information (Chemocare)[3]
- Methotrexate (MTX) patient drug information (UpToDate)[4]
Also known as
Abitrexate, Alltrex, Amethopterin, Antifolan, APO-Methotrexate, Artrait, Biometrox, Biotrexate, Caditrex, Cytotrexate, Ebetrexat, Emthexat, Emthexate, Emthexate PF, Emthexate S, Ervemin, Farmitrexat, Fauldmetro, Folex PFS, Folitrax, Hextrate, Ifamet, Imutrex,Ledertrexate, Ledertrexate Sodium, Ledertrexato, Lumexon, Matrex, Maxtrex, Medsatrexate, Merex, Metex, Methobax, Methoblastin, Methorex, Methotrexaat, Methotrexaat Sandoz, Methotrexat Biosyn, Methotrexat Ebewe, Methotrexate Bigmar, Methotrexate Bristol, Methotrexate DBL, Methotrexate Disodium, Methotrexate DUP, Methotrexate Ebewe, Methotrexate Farmos, Methotrexate Knoll, Methotrexate Lederle, Methotrexate LPF, Methotrexate Mayne, Methotrexate Merck, Methotrexate Paranova, Methotrexate R, Methotrexate Remedica, Methotrexate Singad, Methotrexate Sodium, Methotrexate Sodium Lederle, Methotrexate Teva, Methotrexate Wyeth, Methotrexat Lederle, Methotrexat Medac, Methotrexato, Methotrexat Ridupharm, Methotrexat Teva, Methotrexatum, Meticil, Metolate, Metotressato, Metotrexate, Metotrexato Asofarma, Metotrexato Chiesi, Metotrexato Dosa, Metotrexato Filaxis, Metotrexato Lederle, Metotrexato Martian, Metotrexato Microsules, Metotrexol, Metrex, Metrexan, Metrexato, Metrotex, Mexate, Miantrex CS, MTX, MTX Hexal, Neometho, Neotrexate, Novatrex, Oncotrex, Oncotrex-PF, O Trexat, P&U Methotrexate, Pharmatrexate, Ratio-Methotrexate, Remtrex, Reumatrex, Rextop, Rheumatrex, Tecnomet, Texate, Texate T, Texorate, Tratoben, Trav Methotrexate, Tremetex, Trexall, Trexan, Trexeron, Trixilem, Trixilem RU, Unitrexate, Vero Methotrexate, Zexate
History of changes in FDA indication
- 12/7/1953: Initial FDA approval
References
- Drug index
- Chemotherapy
- Antimetabolites
- Antifolates
- Acute lymphocytic leukemia medications
- Acute promyelocytic leukemia medications
- Aggressive Non-Hodgkin lymphoma medications
- Bladder cancer medications
- Bone cancer medications
- Breast cancer medications
- Central nervous system (CNS) lymphoma medications
- Head and neck cancer medications
- HIV-associated lymphoma medications
- Mantle cell lymphoma medications
- Penile cancer medications
- Prostate cancer medications
- Small cell lung cancer medications
- T-cell lymphoma medications
- Transplant medications
- Drugs FDA approved in 1953