Difference between revisions of "Sorafenib Dosing Nomogram"

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=AAML1031 Sorafenib Dosing Nomogram==
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=AAML1031 Sorafenib Dosing Nomogram=
  
 
{| class="wikitable" style="width: 40%; text-align:center;"  
 
{| class="wikitable" style="width: 40%; text-align:center;"  
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(800 mg)
 
(800 mg)
 
|-
 
|-
−
 
+
|0.41 - 0.45
 +
|50 mg x 6 days/week,
 +
0 x 1 day/week
 +
(300 mg)
 +
|50 mg x 2 days/week,
 +
100 mg x 5 days/week
 +
(600 mg)
 +
|50 mg twice daily x 5 days/week +
 +
100 mg twice daily x 2 days/week
 +
(900 mg)
 +
|-
 +
|0.46 - 0.55
 +
|50 mg x 7 days/week
 +
(350 mg)
 +
|100 mg x 7 days/week
 +
(700 mg)
 +
|50 mg q AM +100 mg q PM
 +
x 7 days/week
 +
(1050 mg)
 +
|-
 +
|0.56 - 0.6
 +
|50 mg x 6 days/week,
 +
100 mg x 1 day/week
 +
(400 mg)
 +
|100 mg x 6 days/week,
 +
200 mg x 1 day/week
 +
(800 mg)
 +
|50 mg twice daily x 2 days/week +
 +
100 mg twice daily x 5 days/week
 +
(1200 mg)
 +
|-
 +
|0.61 - 0.7
 +
|50 mg x 5 days/week,
 +
100 mg x 2 days/week
 +
(450 mg)
 +
|100 mg x 5 days/week,
 +
200 x 2 days/week
 +
(900 mg)
 +
|100 mg twice daily x 7 days/week
 +
(1400 mg)
 +
|-
 +
|0.71 - 0.8
 +
|50 mg x4 days/week,
 +
100 mg x3 days/week
 +
(500 mg)
 +
|150 mg x 7 days/week
 +
(1050mg)
 +
|100 mg twice daily x 5 days/week +
 +
150 mg twice daily x 2 days/week
 +
(1600 mg)
 +
|-
 +
|0.81 - 0.9
 +
|50 mg x 2 days/week,
 +
100 mg x 5 days/week
 +
(600 mg)
 +
|150 mg x 4 days/week,
 +
200 mg x 3
 +
days/week
 +
(1200 mg)
 +
|100 mg q AM + 150 mg q PM
 +
x 7 days/week
 +
(1750 mg)
 +
|-
 +
|0.91 - 01.05
 +
|100 mg x 7 days/week
 +
(700 mg)
 +
|200 mg x 7 days/week
 +
(1400 mg)
 +
|150 mg twice daily x 7 days/week
 +
(2100 mg)
 +
|-
 +
|1.06 - 1.2
 +
|100 mg x 6 days/week,
 +
200 mg x1 day/week
 +
(800 mg)
 +
|200
 +
mg x 3 days/week,
 +
250 mg x 4 days/week
 +
(1600 mg)
 +
|150 mg q AM + 200 mg q PM
 +
x 7 days/week
 +
(2450 mg)
 +
|-
 +
|1.21 - 1.35
 +
|100 mg x 5 days/week,
 +
200 mg x 2 days/week
 +
(900 mg)
 +
|250 mg x 7 days/week
 +
(1750 mg)
 +
|200 mg twice daily x 7 days/week
 +
(2800 mg)
 +
|-
 +
|1.36 - 1.6
 +
|100 mg x 4 days/week,
 +
200 mg x 3 days/week
 +
(1000 mg)
 +
|300 mg x 7 days/week
 +
(2100 mg)
 +
|200 mg q AM + 250 mg q PM
 +
x 7 days/week
 +
(3150 mg)
 +
|-
 +
|1.61 - 1.7
 +
|100 mg x 2 days/week,
 +
200 mg x 5 days/week
 +
(1200 mg)
 +
|350 mg x 7 days/week
 +
(2450 mg)
 +
|250 mg twice daily x 7
 +
days/week
 +
(3500 mg)
 +
|-
 +
|1.71 - 1.85
 +
|100 mg x 1 day/week,
 +
200 mg x 6 days/week
 +
(1300 mg)
 +
|350 mg x 3 days/week
 +
400 mg x 4 days/week
 +
(2650 mg)
 +
|250 mg q AM + 300 mg q PM
 +
x 7 days/week
 +
(3850 mg)
 
|-
 
|-
−
 
+
|≥ 1.86
 +
|200 mg x 7 days/week
 +
(1400 mg)
 +
|400 mg x 7 days/week
 +
(2800 mg)
 +
|300 mg twice daily x 7 days /week
 +
(4200 mg)
 
|}
 
|}

Revision as of 00:27, 3 September 2021

Section editor transclusions This page contains studies that were specific to pediatric populations. For the more general AML page, follow this link.

0 regimens on this page
0 variants on this page


AAML1031 Sorafenib Dosing Nomogram

BSA Range (m2) Dose Level 0 (100 mg/m2/day once daily) Dose Level 1 (200 mg/m2/day once daily) Dose Level 2 (300 mg/m2/day divided BID)
≤ 0.35 50 mg x 4 days/week,

0 x 3 day/week (200 mg)

50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

50 mg twice daily x 7 days/week

(700 mg)

0.36 - 0.4 50 mg x 5 days/week,

0 x 2 day/week (250 mg)

50 mg x 4 days/week,

100 mg x 3 days/week (500 mg)

50 mg twice daily x 6 days/week +

100 mg twice daily x 1 day/week (800 mg)

0.41 - 0.45 50 mg x 6 days/week,

0 x 1 day/week (300 mg)

50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

50 mg twice daily x 5 days/week +

100 mg twice daily x 2 days/week (900 mg)

0.46 - 0.55 50 mg x 7 days/week

(350 mg)

100 mg x 7 days/week

(700 mg)

50 mg q AM +100 mg q PM

x 7 days/week (1050 mg)

0.56 - 0.6 50 mg x 6 days/week,

100 mg x 1 day/week (400 mg)

100 mg x 6 days/week,

200 mg x 1 day/week (800 mg)

50 mg twice daily x 2 days/week +

100 mg twice daily x 5 days/week (1200 mg)

0.61 - 0.7 50 mg x 5 days/week,

100 mg x 2 days/week (450 mg)

100 mg x 5 days/week,

200 x 2 days/week (900 mg)

100 mg twice daily x 7 days/week

(1400 mg)

0.71 - 0.8 50 mg x4 days/week,

100 mg x3 days/week (500 mg)

150 mg x 7 days/week

(1050mg)

100 mg twice daily x 5 days/week +

150 mg twice daily x 2 days/week (1600 mg)

0.81 - 0.9 50 mg x 2 days/week,

100 mg x 5 days/week (600 mg)

150 mg x 4 days/week,

200 mg x 3 days/week (1200 mg)

100 mg q AM + 150 mg q PM

x 7 days/week (1750 mg)

0.91 - 01.05 100 mg x 7 days/week

(700 mg)

200 mg x 7 days/week

(1400 mg)

150 mg twice daily x 7 days/week

(2100 mg)

1.06 - 1.2 100 mg x 6 days/week,

200 mg x1 day/week (800 mg)

200

mg x 3 days/week, 250 mg x 4 days/week (1600 mg)

150 mg q AM + 200 mg q PM

x 7 days/week (2450 mg)

1.21 - 1.35 100 mg x 5 days/week,

200 mg x 2 days/week (900 mg)

250 mg x 7 days/week

(1750 mg)

200 mg twice daily x 7 days/week

(2800 mg)

1.36 - 1.6 100 mg x 4 days/week,

200 mg x 3 days/week (1000 mg)

300 mg x 7 days/week

(2100 mg)

200 mg q AM + 250 mg q PM

x 7 days/week (3150 mg)

1.61 - 1.7 100 mg x 2 days/week,

200 mg x 5 days/week (1200 mg)

350 mg x 7 days/week

(2450 mg)

250 mg twice daily x 7

days/week (3500 mg)

1.71 - 1.85 100 mg x 1 day/week,

200 mg x 6 days/week (1300 mg)

350 mg x 3 days/week

400 mg x 4 days/week (2650 mg)

250 mg q AM + 300 mg q PM

x 7 days/week (3850 mg)

≥ 1.86 200 mg x 7 days/week

(1400 mg)

400 mg x 7 days/week

(2800 mg)

300 mg twice daily x 7 days /week

(4200 mg)

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