Difference between revisions of "Topotecan (Hycamtin)"
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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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| + | ==Diseases for which it is used== | ||
| + | *[[Aggressive Non-Hodgkin lymphoma]] | ||
| + | *[[Bone cancer]] | ||
| + | *[[Cervical cancer]] | ||
| + | *[[Ovarian cancer]] | ||
| + | *[[Small cell lung cancer]] | ||
| + | *[[Uterine cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| Line 11: | Line 19: | ||
==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
| − | * 5/28/1996: Initial FDA approval | + | * 5/28/1996: Initial FDA approval for metastatic [[Ovarian cancer | carcinoma of the ovary]] after failure of initial or subsequent chemotherapy. |
| + | * 11/30/1998: Indication expanded to include [[Small cell lung cancer | small cell lung cancer]] sensitive disease after failure of first-line chemotherapy. In clinical studies submitted to support approval, sensitive disease was defined as disease responding to chemotherapy but subsequently progressing at least 60 days (in the phase 3 study) or at least 90 days (in the phase 2 studies) after chemotherapy. | ||
| + | * 6/14/2006: Indication expanded to include stage IV-B, recurrent, or persistent [[Cervical cancer | carcinoma of the cervix]] which is not amenable to curative treatment with surgery and/or radiation therapy. | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | [[Category:Drug index]] | ||
[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
Revision as of 14:19, 25 October 2014
General information
Class/mechanism: Topoisomerase I inhibitor. Topotecan binds to the topoisomerase I-DNA complex and prevents the religation of single strand breaks that were originally created by topoisomerase I. This leads to double strand DNA damage, which results in cell damage and cell death.[1][2]
Route: IV
Extravasation: irritant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Aggressive Non-Hodgkin lymphoma
- Bone cancer
- Cervical cancer
- Ovarian cancer
- Small cell lung cancer
- Uterine cancer
Patient drug information
- Topotecan (Hycamtin) patient drug information (Chemocare)[3]
- Topotecan (Hycamtin) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 5/28/1996: Initial FDA approval for metastatic carcinoma of the ovary after failure of initial or subsequent chemotherapy.
- 11/30/1998: Indication expanded to include small cell lung cancer sensitive disease after failure of first-line chemotherapy. In clinical studies submitted to support approval, sensitive disease was defined as disease responding to chemotherapy but subsequently progressing at least 60 days (in the phase 3 study) or at least 90 days (in the phase 2 studies) after chemotherapy.
- 6/14/2006: Indication expanded to include stage IV-B, recurrent, or persistent carcinoma of the cervix which is not amenable to curative treatment with surgery and/or radiation therapy.