Ipilimumab (Yervoy)

General information

Class/mechanism: Anti-CTLA-4 antibody. CTLA-4 is a negative regulator of T-cell activation and ipilimumab interferes with the ability of CTLA-4 to interact with its ligands CD80/CD86. CTLA-4 blockade results in T-cell activation and proliferation, and it is suspected that its anti-neoplastic activity may be due to T-cell mediated anti-tumor immune responses.
Route: IV
Extravasation: no information

• YERVOY Risk Evaluation and Mitigation Strategy (REMS) Site

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Melanoma
• Non-small cell lung cancer

Patient drug information

• Ipilimumab (Yervoy) package insert
• Ipilimumab (Yervoy) patient drug information (Chemocare)
• Ipilimumab (Yervoy) patient drug information (UpToDate)

History of changes in FDA indication

• 3/25/2011: FDA approved "for the treatment of unresectable or metastatic melanoma."

Also known as

BMS-734016 or MDX-010.