Difference between revisions of "Docetaxel (Taxotere)"

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For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer.  Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref>  
 
==Diseases for which it is used==
 
*[[Bone cancer]]
 
*[[Breast cancer]]
 
*[[Unknown primary|Cancer of unknown primary]]
 
*[[Cervical cancer]]
 
*[[Esophageal cancer]]
 
*[[Head and neck cancer]]
 
*[[Melanoma]]
 
*[[Non-small cell lung cancer]]
 
*[[Ovarian cancer]]
 
*[[Pancreatic cancer]]
 
*[[Prostate cancer]]
 
*[[Sarcoma]]
 
*[[Small cell lung cancer]]
 
  
 
==Patient drug information==
 
==Patient drug information==
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[[Category:Microtubule inhibitors]]
 
[[Category:Microtubule inhibitors]]
 
[[Category:Taxanes]]
 
[[Category:Taxanes]]
 +
 
[[Category:Bone cancer medications]]  
 
[[Category:Bone cancer medications]]  
 
[[Category:Breast cancer medications]]
 
[[Category:Breast cancer medications]]
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[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]
 +
[[Category:Head and neck cancer medications]]
 +
[[Category:Melanoma medications]]
 
[[Category:Non-small cell lung cancer medications]]
 
[[Category:Non-small cell lung cancer medications]]
 
[[Category:Ovarian cancer medications]]
 
[[Category:Ovarian cancer medications]]
 
[[Category:Pancreatic cancer medications]]  
 
[[Category:Pancreatic cancer medications]]  
 
[[Category:Prostate cancer medications]]
 
[[Category:Prostate cancer medications]]
 +
[[Category:Sarcoma medications]]
 +
[[Category:Small cell lung cancer medications]]

Revision as of 19:21, 11 June 2014

General information

Class/mechanism: Taxane; disrupts normal microtubular function. Binds to free tubulin, promotes their assembly into stable microtubules, and inhibits their disassembly, which inhibits mitosis.[1][2]
Route: IV
Extravasation: irritant, rare vesicant

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information

Also known as

Asodocel, Docetax, Docetaxel Comp, Docetaxel Delta Farma, Docetaxel Microsules, Docetaxel Sandoz, Docetere, Dolectran, Doxel, Doxetal, Oncodocel, Plustaxano, N-debenzoyl-N-tert-butoxycarbonyl-10-deacetyl Taxol, Neocel, NSC 628503, RP 56976, Taxotere Aventis, Taxotere Chugai, Texot, Trixotene.

References