Difference between revisions of "Giant-cell tumor of bone"
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## '''Update:''' Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, Schuetze SM, Henshaw R, Dai T, Jandial D, Palmerini E. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019 Dec;20(12):1719-1729. Epub 2019 Nov 6. [https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30663-1/fulltext link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/31704134 PubMed] | ## '''Update:''' Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, Schuetze SM, Henshaw R, Dai T, Jandial D, Palmerini E. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019 Dec;20(12):1719-1729. Epub 2019 Nov 6. [https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(19)30663-1/fulltext link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/31704134 PubMed] | ||
− | [[Category:Giant cell tumor of bone regimens]] | + | [[Category:Giant-cell tumor of bone regimens]] |
[[Category:Disease-specific pages]] | [[Category:Disease-specific pages]] | ||
[[Category:Bone sarcomas]] | [[Category:Bone sarcomas]] |
Revision as of 03:23, 29 January 2020
Section editor | |
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Elizabeth J. Davis, MD Vanderbilt University Nashville, TN ![]() |
1 regimens on this page
1 variants on this page
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All lines of therapy
Denosumab monotherapy
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Regimen
Study | Evidence |
---|---|
Thomas et. al 2010 (Amgen 20040215) | Phase II (RT) |
Chawla et al. 2013 (Amgen 20062004) | Phase II (RT) |
Chemotherapy
- Denosumab (Xgeva) as follows:
- Cycle 1: 120 mg SC once per day on days 1, 8, 15
- Cycle 2 onwards: 120 mg SC once on day 1
Supportive medications
- Calcium 500 mg PO once per day
- Vitamin D 400 IU PO once per day
28-day cycles
References
- Amgen 20040215: Thomas D, Henshaw R, Skubitz K, Chawla S, Staddon A, Blay JY, Roudier M, Smith J, Ye Z, Sohn W, Dansey R, Jun S. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol. 2010 Mar;11(3):275-80. link to original article contains verified protocol PubMed
- Amgen 20062004: Chawla S, Henshaw R, Seeger L, Choy E, Blay JY, Ferrari S, Kroep J, Grimer R, Reichardt P, Rutkowski P, Schuetze S, Skubitz K, Staddon A, Thomas D, Qian Y, Jacobs I. Safety and efficacy of denosumab for adults and skeletally mature adolescents with giant cell tumour of bone: interim analysis of an open-label, parallel-group, phase 2 study. Lancet Oncol. 2013 Aug;14(9):901-8. Epub 2013 Jul 16. link to original article contains protocol PubMed
- Update: Chawla S, Blay JY, Rutkowski P, Le Cesne A, Reichardt P, Gelderblom H, Grimer RJ, Choy E, Skubitz K, Seeger L, Schuetze SM, Henshaw R, Dai T, Jandial D, Palmerini E. Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. Lancet Oncol. 2019 Dec;20(12):1719-1729. Epub 2019 Nov 6. link to original article PubMed