Difference between revisions of "HemOnc vocabulary concepts"
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*Examples: acquired coagulopathy, acute myeloid leukemia, adrenocortical carcinoma | *Examples: acquired coagulopathy, acute myeloid leukemia, adrenocortical carcinoma | ||
==Condition Class== | ==Condition Class== | ||
| − | Examples: classical hematologic condition, leukemia, malignant solid neoplasm | + | Condition classes are containers for a subset of conditions. Most of these are organized by anatomy or disease category. |
| + | *Examples: classical hematologic condition, leukemia, malignant solid neoplasm | ||
==Context== | ==Context== | ||
| − | Examples: adjuvant therapy, non-curative first-line induction therapy, upfront therapy | + | Context refers to the disease setting in which a treatment is administered. There are currently 33 contexts described in the HemOnc vocabulary, organized into a hierarchical structure with ''is a'' relationships. |
| + | *Examples: adjuvant therapy, non-curative first-line induction therapy, upfront therapy | ||
| + | *Example of relationships: adjuvant therapy ''is a'' post-definitive therapy ''is an'' upfront therapy ''is a'' curative therapy ''is an'' all lines of therapy | ||
=Regimen-level concepts= | =Regimen-level concepts= | ||
Revision as of 21:02, 27 January 2020
This page has short descriptions and examples of the concepts that have been parsed into the HemOnc ontology. Note that this is NOT the full HemOnc chemotherapy regimen model, as there are still concepts that are in the process of being defined and parsed. For information about how to obtain a copy of the ontology please go to this page.
Condition-level concepts
Condition
In the HemOnc vocabulary, a condition is the granular level at which treatments have been evaluated. For example, Colon cancer and Rectal cancer are conditions, whereas Colorectal cancer is a Condition Class.
- Examples: acquired coagulopathy, acute myeloid leukemia, adrenocortical carcinoma
Condition Class
Condition classes are containers for a subset of conditions. Most of these are organized by anatomy or disease category.
- Examples: classical hematologic condition, leukemia, malignant solid neoplasm
Context
Context refers to the disease setting in which a treatment is administered. There are currently 33 contexts described in the HemOnc vocabulary, organized into a hierarchical structure with is a relationships.
- Examples: adjuvant therapy, non-curative first-line induction therapy, upfront therapy
- Example of relationships: adjuvant therapy is a post-definitive therapy is an upfront therapy is a curative therapy is an all lines of therapy
Regimen-level concepts
Cycle Sigs
Examples: 14-day cycle for up to 8 cycles, 21-day cycle for 4 cycles, 21-day cycle for up to 35 cycles (2 years)
Modality
Examples: anticoagulation, chemotherapy, immunotherapy
Regimen
Examples: 7 plus 3d, 7 plus 3d and Midostaurin, R-CHOP
Regimen Class
Examples: platinum doublet, bevacizumab-containing regimen
Regimen Stub
Examples: FULV and Trimetrexate, Plitidespin and Dexamethasone
Component-level concepts
Brand Name
These are US and non-US brand names for drugs.
- Examples: Abatoarin, Acetisal, Aclacin
Component
Examples: abciximab, abemaciclib, abexinostat
Component Class
Examples: 5 alpha-reductase inhibitor, AKT1 inhibitor, anthracycline
Procedure
Examples: adrenalectomy, lymphadenectomy, interval debulking surgery
Rad Sig
Example: 1.1 Gy fractions x 70 fractions, given twice per day, 5 times per week (total dose: 77 Gy)
Route
Examples: intravenous, oral, subcutaneous
Sig
Example: 0.4 mg/m^2/day IV continuous infusion over 96 hours, started on day 1 (total dose per cycle: 1.6 mg/m^2)
Sig Stub
Example: (dose not specified) IT once per day on days 22 and 43
Study-level concepts
Endpoint
Examples: CR rate after first induction, DFS36, OS
Experimental design
Examples: de-escalation, escalation, in-class switch, out-of-class switch
Study
Examples: ABSOLUTE, ACOSOG Z1031, ECOG E3483
Study Class
Example: FDA registration study
Study Group
Examples: Eastern Cooperative Oncology Group, EINSTEIN Investigators, EORTC Children Leukemia Group
Study name short
Examples: Adelstein et al. 2003, Adelstein et al. 2010, Alberts et al. 1989
Publication-level concepts
Journal
Examples: Blood Adv, N Engl J Med, Ann Oncol
PubMedURL
Most of the references included in the HemOnc vocabulary are also indexed in MEDLINE. When this is the case, we also include a direct hyperlink to the PubMed abstract.
Reference
Examples: ABSOLUTE::00, Abrey et al. 2000::01
ReferenceTitle
Example: A comparative study of two regimens of combination chemotherapy in acute leukemia
ReferenceURL
This is the direct hyperlink to the publication described by the Reference concept.
Author-level concepts
Author
Author names, in the format of Last-Name_First/Middle.
- Examples: Abbruzzese_Alberto, Abbruzzese_James L, Abernethy_Amy
Generic concepts
Year
Examples: 1946, 2020