Difference between revisions of "Leucovorin (Folinic acid)"

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==Also known as==
 
==Also known as==
 +
*'''Generic names:''' citrovorum factor, folinate calcium, folinato de calcio, LV, sodium folinate
 +
*'''Brand names:'''
 
{| class="wikitable" style="text-align:center;"
 
{| class="wikitable" style="text-align:center;"
 
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
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|Buateron
 
|Buateron
 
|Calcifolin
 
|Calcifolin
−
|Calcio Folinato
 
 
|Calciumfolin
 
|Calciumfolin
 
|Calciumfolinat
 
|Calciumfolinat
 +
|Calcium Folinato
 
|-
 
|-
−
|Calcium Folinato
 
 
|Calcium Folint
 
|Calcium Folint
 
|Calcium Leucovorin
 
|Calcium Leucovorin
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|Calfolex
 
|Calfolex
 
|Calfolin
 
|Calfolin
 +
|Calinat
 
|-
 
|-
−
|Calinat
 
 
|Cehafolin
 
|Cehafolin
 
|Citofolin
 
|Citofolin
−
|Citrovorum Factor
 
 
|Claro
 
|Claro
 
|Cromatonbic Folinico
 
|Cromatonbic Folinico
 
|Dalisol
 
|Dalisol
 
|Degalin
 
|Degalin
−
|-
 
 
|Divifolin
 
|Divifolin
 
|Durofolin
 
|Durofolin
 +
|-
 
|Ecofol
 
|Ecofol
 
|Elvefocal
 
|Elvefocal
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|Estroquin
 
|Estroquin
 
|Fastovorin
 
|Fastovorin
−
|-
 
 
|Fauldleuco
 
|Fauldleuco
 
|Fayining
 
|Fayining
 +
|-
 
|Fedolen
 
|Fedolen
 
|Ferbon
 
|Ferbon
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|Foliben
 
|Foliben
 
|Foli Cell
 
|Foli Cell
−
|-
 
 
|Folidan
 
|Folidan
 
|Folidar
 
|Folidar
 +
|-
 
|Foliment
 
|Foliment
 
|Folinac
 
|Folinac
−
|Folinate Calcium
 
 
|Folinato
 
|Folinato
 
|Folinfabra
 
|Folinfabra
 
|Folinoral
 
|Folinoral
−
|-
 
 
|Folinoxan
 
|Folinoxan
 
|Folinvit
 
|Folinvit
 
|Foliplus
 
|Foliplus
 +
|-
 
|Folmigor
 
|Folmigor
 
|Ifavor
 
|Ifavor
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|Kalciumfolinat Perivita
 
|Kalciumfolinat Perivita
 
|Kalsiumfolinat
 
|Kalsiumfolinat
−
|-
 
 
|Kunyrin
 
|Kunyrin
 
|Lederfolat
 
|Lederfolat
 
|Lederfolin
 
|Lederfolin
 +
|-
 
|Lederfoline
 
|Lederfoline
−
|Lederle Leucovorin
 
 
|Ledervorin
 
|Ledervorin
 
|Legifol
 
|Legifol
 
|Leucocalcin
 
|Leucocalcin
−
|-
 
 
|Leuconolver
 
|Leuconolver
 +
|Leucovorin
 
|Leucovorina
 
|Leucovorina
 
|Leucovorine
 
|Leucovorine
 +
|-
 
|Leukovorin
 
|Leukovorin
 
|Lovorin
 
|Lovorin
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|Medifolin
 
|Medifolin
 
|Medsavorina
 
|Medsavorina
−
|-
 
 
|Neofolin
 
|Neofolin
 
|Nyrin
 
|Nyrin
 
|O Folin
 
|O Folin
 +
|-
 
|Osfolate
 
|Osfolate
 
|Osfolato
 
|Osfolato
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|Prefolic
 
|Prefolic
 
|Prevax
 
|Prevax
−
|-
 
 
|Recovorin
 
|Recovorin
 
|Reotan
 
|Reotan
 
|Rescuvolin
 
|Rescuvolin
 +
|-
 
|Resfolin
 
|Resfolin
 
|Ribofolin
 
|Ribofolin
 
|Rontafor
 
|Rontafor
 
|Sanifolin
 
|Sanifolin
−
|Sodium Folinate
 
−
|-
 
 
|Tecnovorin
 
|Tecnovorin
 
|Tonofolin
 
|Tonofolin
 
|Veravorin
 
|Veravorin
 
|Vorina
 
|Vorina
 +
|-
 
|Wellcovorin
 
|Wellcovorin
 
|Zyofolin
 
|Zyofolin

Revision as of 21:08, 24 June 2019

General information

Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Patient drug information

History of changes in FDA indication

  • 6/20/1952: Initial FDA approval

Also known as

  • Generic names: citrovorum factor, folinate calcium, folinato de calcio, LV, sodium folinate
  • Brand names:
Synonyms
Antrex Asovorin Biovorin Buateron Calcifolin Calciumfolin Calciumfolinat Calcium Folinato
Calcium Folint Calcium Leucovorin Calcium Leucovorn Calcivoran Calc Leucovorn Calfolex Calfolin Calinat
Cehafolin Citofolin Claro Cromatonbic Folinico Dalisol Degalin Divifolin Durofolin
Ecofol Elvefocal Emovis Erbanfol Estroquin Fastovorin Fauldleuco Fayining
Fedolen Ferbon Folaren Folaxin Foliben Foli Cell Folidan Folidar
Foliment Folinac Folinato Folinfabra Folinoral Folinoxan Folinvit Foliplus
Folmigor Ifavor Isovorin Kalciumfolinat Perivita Kalsiumfolinat Kunyrin Lederfolat Lederfolin
Lederfoline Ledervorin Legifol Leucocalcin Leuconolver Leucovorin Leucovorina Leucovorine
Leukovorin Lovorin Medicofolin Medifolin Medsavorina Neofolin Nyrin O Folin
Osfolate Osfolato Perfolate Prefolic Prevax Recovorin Reotan Rescuvolin
Resfolin Ribofolin Rontafor Sanifolin Tecnovorin Tonofolin Veravorin Vorina
Wellcovorin Zyofolin Zytofolin

References

  1. ↑ 1.0 1.1 Folinic acid (Leucovorin) package insert
  2. ↑ Folinic acid (Leucovorin) package insert (locally hosted backup)
  3. ↑ Folinic acid (Leucovorin) patient drug information (Chemocare)
  4. ↑ Folinic acid (Leucovorin) patient drug information (UpToDate)
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