Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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Warner-admin (talk | contribs) m (Text replacement - "Autoimmune thrombocytopenic purpura (ITP)" to "Immune thrombocytopenia (ITP)") |
Warner-admin (talk | contribs) m (Text replacement - "hemolytic-uremic" to "hemolytic uremic") |
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| Line 12: | Line 12: | ||
*Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | *Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | ||
*[[Peripheral smear findings|Peripheral smear]], platelet clumps | *[[Peripheral smear findings|Peripheral smear]], platelet clumps | ||
| − | *Clinical history (bleeding, temporality, recent infections), [[Thrombotic thrombocytopenic purpura|TTP]]/[[Atypical hemolytic | + | *Clinical history (bleeding, temporality, recent infections), [[Thrombotic thrombocytopenic purpura|TTP]]/[[Atypical hemolytic uremic syndrome (aHUS)|aHUS]] |
*Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | *Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) | ||
*Lifestyle factors (e.g. alcohol) | *Lifestyle factors (e.g. alcohol) | ||
| Line 24: | Line 24: | ||
==Relevant diagnoses== | ==Relevant diagnoses== | ||
| − | *[[Atypical hemolytic | + | *[[Atypical hemolytic uremic syndrome (aHUS)]] |
*[[Immune thrombocytopenia (ITP)]] | *[[Immune thrombocytopenia (ITP)]] | ||
*[[Heparin-induced thrombocytopenia (HIT)]] | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
Revision as of 19:09, 1 March 2019
Definition
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP