Difference between revisions of "Fotemustine (Muphoran)"
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From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=38865 NCI Drug Dictionary]: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. | From the [http://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=38865 NCI Drug Dictionary]: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier. | ||
− | == | + | ==Diseases for which it is used== |
+ | *[[Melanoma]] | ||
− | == | + | ==Also known as== |
− | + | *'''Brand names:''' Muphoran, Mustophoran | |
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[[Category:Drugs]] | [[Category:Drugs]] | ||
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[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
[[Category:Nitrosoureas]] | [[Category:Nitrosoureas]] | ||
− | [[Category: | + | [[Category:Melanoma medications]] |
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− | [[Category: | + | [[Category:EMA approved drugs]] |
Revision as of 01:25, 12 August 2018
Mechanism of action
From the NCI Drug Dictionary: A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
Diseases for which it is used
Also known as
- Brand names: Muphoran, Mustophoran