Difference between revisions of "Lenvatinib (Lenvima)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Hepatocellular carcinoma]] | *[[Hepatocellular carcinoma]] | ||
| − | *[[Renal | + | *[[Renal cell carcinoma]] |
*[[Thyroid cancer]] | *[[Thyroid cancer]] | ||
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==History of changes in FDA indication== | ==History of changes in FDA indication== | ||
*2/13/2015: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm434347.htm FDA approved] for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory [[Thyroid_cancer|differentiated thyroid cancer]]. | *2/13/2015: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm434347.htm FDA approved] for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory [[Thyroid_cancer|differentiated thyroid cancer]]. | ||
| − | *5/13/2016: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm501070.htm FDA approved] in combination with [[Everolimus (Afinitor)|everolimus]], for the treatment of advanced [[Renal | + | *5/13/2016: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm501070.htm FDA approved] in combination with [[Everolimus (Afinitor)|everolimus]], for the treatment of advanced [[Renal cell carcinoma|renal cell carcinoma]] following one prior [[:Category:VEGFR_inhibitors|anti-angiogenic therapy]]. |
==Also known as== | ==Also known as== | ||
Revision as of 12:53, 30 July 2018
General information
Class/mechanism: Tyrosine kinase inhibitor of multiple receptor tyrosine kinases (RTKs), including: vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4); fibroblast growth factor (FGF) receptors FGFR1, FGFR2, FGFR3, and FGFR4; platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. Inhibition of these receptor tyrosine kinases interferes with cancer cells' proliferation and pathogenic angiogenesis.[1][2][3]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert.[1]
Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 2/13/2015: FDA approved for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer.
- 5/13/2016: FDA approved in combination with everolimus, for the treatment of advanced renal cell carcinoma following one prior anti-angiogenic therapy.
Also known as
- Code name: E7080
- Brand name: Lenvima