Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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Warner-admin (talk | contribs) m (Text replacement - "Autoimmune thrombocytopenic purpura (ITP)" to "Immune thrombocytopenia (ITP)") |
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==Relevant diagnoses== | ==Relevant diagnoses== | ||
*[[Atypical hemolytic-uremic syndrome (aHUS)]] | *[[Atypical hemolytic-uremic syndrome (aHUS)]] | ||
| − | *[[ | + | *[[Immune thrombocytopenia (ITP)]] |
*[[Heparin-induced thrombocytopenia (HIT)]] | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
*[[Thrombocytopenia in liver disease]] | *[[Thrombocytopenia in liver disease]] | ||
Revision as of 01:49, 24 July 2018
Definition
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP