Rho(D) immune globulin (RhoGAM)

General information

Class/mechanism: Not entirely known. Rho(D) immune globulin forms anti-D-coated red blood cell complexes which are thought to bind to macrophage receptors in the spleen. This is then hypothesized to block the spleen's clearance of antibody-coated cells, which include platelets. Thus, the destruction of platelets in ITP is limited.
Route: IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• Autoimmune thrombocytopenic purpura (ITP)

Patient drug information

• Rho(D) immune globulin (RhoGAM) patient drug information (UpToDate)