Difference between revisions of "Acute myeloid leukemia, IDH-mutated"
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=Investigational agents= | =Investigational agents= | ||
''These are drugs under study with at least some promising results for this disease.'' | ''These are drugs under study with at least some promising results for this disease.'' | ||
− | *[[Ivosidenib (AG-120)]] | + | *[[Ivosidenib (AG-120)]] |
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[[Category:Acute myeloid leukemia regimens]] | [[Category:Acute myeloid leukemia regimens]] | ||
[[Category:Biomarker-specific pages]] | [[Category:Biomarker-specific pages]] | ||
[[Category:Acute leukemias]] | [[Category:Acute leukemias]] |
Revision as of 02:33, 22 June 2018
Page editor | |
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Martin Schoen, MD, MPH St. Louis, MO |
Note: these are biomarker-specific regimens for patients with IDH-mutated AML, please see the main AML page for other regimens.
8 regimens on this page
8 variants on this page
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IDH2 Relapsed or refractory, salvage therapy
Enasidenib monotherapy
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Regimen
FDA-recommended dose |
Study | Evidence | Efficacy |
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Stein et al. 2017 | Phase I/II | ORR: 40% |
This is the dose used in the phase II expansion cohort; enrolled patients were required to have IDH2-mutated advanced myeloid malignancies.
Chemotherapy
- Enasidenib (Idhifa) 100 mg PO once per day
28-day cycles
References
- Stein EM, DiNardo CD, Pollyea DA, Fathi AT, Roboz GJ, Altman JK, Stone RM, DeAngelo DJ, Levine RL, Flinn IW, Kantarjian HM, Collins R, Patel MR, Frankel AE, Stein A, Sekeres MA, Swords RT, Medeiros BC, Willekens C, Vyas P, Tosolini A, Xu Q, Knight RD, Yen KE, Agresta S, de Botton S, Tallman MS. Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia. Blood. 2017 Aug 10;130(6):722-731. Epub 2017 Jun 6. link to original article contains verified protocol link to PMC article PubMed
Investigational agents
These are drugs under study with at least some promising results for this disease.