Difference between revisions of "Acyclovir (Zovirax)"
(Created page with "Also known as Acic, aciclovir, Acivir, Acivirax, ACV, acycloguanosine, Acylete, Apo-acyclovir, Avorax, Axcel, Cusiviral, Cyclovax, Cyclovir, Declovir, Dravyr, Hepirax, Herpeve...") |
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| − | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/zovirax-acyclovir-342601 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Diseases for which it is used== | ==Diseases for which it is used== | ||
Revision as of 20:45, 24 April 2013
Also known as Acic, aciclovir, Acivir, Acivirax, ACV, acycloguanosine, Acylete, Apo-acyclovir, Avorax, Axcel, Cusiviral, Cyclovax, Cyclovir, Declovir, Dravyr, Hepirax, Herpevex, Herpex, Herzovir, Klovireks-l, Lovir, Medovir, Pharmaniaga, Saforax, Vacrax, Vicide, Virax, Virest, Virless, Virox, Virucid, Virupos, Xovir, Zevin, Zirax, Zoral, Zorax, Zoraxin, Zoviax, Zovir.
General information
Class/mechanism: Antiviral; synthetic purine nucleoside analog which interacts with the viral thymidine kinase (TK) encoded by herpes simplex virus types 1 and 2 (HSV-1 & HSV-2) and the varicella-zoster virus (VZV). Thymidine kinase converts acyclovir to acyclovir monophosphate, which is eventually converted via phosphorylation into acyclovir triphosphate. Acyclovir triphosphate inhibits the replication of viral DNA by prematurely terminating the replicating DNA strand since acyclovir has no 3' end; competitively inhibiting viral DNA polymerase; and inactivating viral DNA polymerase. Acyclovir has greater activity against HSV compared to VZV because of more robust phosphorylation by the HSV viral thymidine kinase.[1][2]
Route: PO, IV, topical
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Mantle cell lymphoma
- Marginal zone lymphoma
- Multiple myeloma
Patient drug information
- Acyclovir (Zovirax) patient drug information (RxList)[3]
- Acyclovir (Zovirax) patient drug information (UpToDate)[4]