Difference between revisions of "Thrombocytopenia and platelet dysfunction"
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==Definition== | ==Definition== | ||
| − | Platelet count | + | Platelet count less than 150 × 10<sup>9</sup>/L or less than the lower limit of normal as defined by a local laboratory. |
==Evaluation== | ==Evaluation== | ||
| Line 12: | Line 12: | ||
*Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | *Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly | ||
*[[Peripheral smear findings|Peripheral smear]], platelet clumps | *[[Peripheral smear findings|Peripheral smear]], platelet clumps | ||
| − | *Clinical history (bleeding, temporality, recent infections), TTP/ | + | *Clinical history (bleeding, temporality, recent infections), [[Thrombotic thrombocytopenic purpura|TTP]]/[[Atypical hemolytic-uremic syndrome (aHUS)|aHUS]] |
| − | *Thrombotic history (e.g. heparin/HIT) | + | *Thrombotic history (e.g., heparin/[[Heparin-induced thrombocytopenia (HIT)|HIT]]) |
*Lifestyle factors (e.g. alcohol) | *Lifestyle factors (e.g. alcohol) | ||
*Medications | *Medications | ||
| Line 22: | Line 22: | ||
*Pregnancy/gestational thrombocytopenia | *Pregnancy/gestational thrombocytopenia | ||
*ITP | *ITP | ||
| + | |||
| + | ==Relevant diagnoses== | ||
| + | *[[Atypical hemolytic-uremic syndrome (aHUS)]] | ||
| + | *[[Autoimmune thrombocytopenic purpura (ITP)]] | ||
| + | *[[Heparin-induced thrombocytopenia (HIT)]] | ||
| + | *[[Thrombocytopenia in liver disease]] | ||
| + | *[[Thrombotic thrombocytopenic purpura]] | ||
[[Category:Hematology reference pages]] | [[Category:Hematology reference pages]] | ||
Revision as of 13:49, 23 May 2018
Definition
Platelet count less than 150 × 109/L or less than the lower limit of normal as defined by a local laboratory.
Evaluation
May consist of:
- CBC with differential
- Comprehensive metabolic panel, including liver function tests (LFTs)
- Vitamin B12
- Folate
- Assessment for liver disease, hepatomegaly, fatty liver, splenomegaly
- Peripheral smear, platelet clumps
- Clinical history (bleeding, temporality, recent infections), TTP/aHUS
- Thrombotic history (e.g., heparin/HIT)
- Lifestyle factors (e.g. alcohol)
- Medications
- Hepatitis serologies
- HIV
- ANA, lupus
- Pseudothrombocytopenia, EDTA-induced clumping (draw sample in blue top citrate tube)
- Pregnancy/gestational thrombocytopenia
- ITP