Trimethoprim-Sulfamethoxazole (Bactrim DS)

General information

Class/mechanism: Sulfonamide antibiotic, combination of trimethoprim and sulfamethoxazole. Sulfamethoxazole and trimethoprim work synergistically to block two consecutive steps of nucleic acid synthesis in bacteria. Sulfamethoxazole is a competitive inhibitor of para-aminobenzoic acid (PABA) and blocks bacterial synthesis of dihydrofolic acid. Trimethoprim reversibly inhibits dihydrofolate reductase, blocking the production of tetrahydrofolic acid from dihydrofolic acid.
Route: PO, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Patient drug information

• Trimethoprim/Sulfamethoxazole (Bactrim DS) patient drug information (UpToDate)

Also known as

Abacin, Abactrim, Abatrim, Abditri, Abetrim, Actrim, Adco-CO-Trimoxazole, Aditrim, Adrenol, Adtrim, Aksotran, Albrotran, Albutrim, Alcorim-F, Alcot, Allibac, Altrim, Amazole, Amoxazol, Amtran, Amtril, Andoprim, Anitrim, Anprim, Antibac, Antrim, Antrimox, Apcetrim, APO-Bactotrim, APO-Sulfatrim DS, APO Sulfatrim, Apotrinelax, Aptrim, Aratran, Ascotran, Aspen Cotrimazole, Assepium, Atomexin, Avlotrin, B.S., BAC-Sulfitrin, Bacfar, Bacidal, Bacin, Bacitran, Bacmetrin, Bacoprim, Bacotrin, Bacprotin, Bacris, Bacsulfaprin, Bacsultrim, Bactar, Bactazol, Bactekod, Bactelan, Bacteracin, Bacterial, Bacteric, Bacteriof.klebs PN, Bacterol, Bacticel, Bactide, Bactifor, Bactigram, Bactille-TS, Bactipront, Bactiseptol, Bactiver, Bactoprim, Bactoprim Combi, Bactoreduct, Bactosain, Bactostab, Bactramin, Bactramin C, Bactricid, Bactricida, Bactricin, Bactrilac, Bactrim, Bactrim-F, Bactrim DS, Bactrimel, Bactrim Forte, Bactrim Paediatric, Bactrim Perfusione, Bactrim Roche, Bactrin, Bactrisan, Bactrium DS, Bactrizole, Bactron, Bactronil, Bactropin, Bacxal, Baczin, Baczole, Baklinger, Baktar, Bakton, Baktrisid DS, Balkatrin, Balkatrine, Balkatrin Forte, Bantizol, Basatin, Baserin, Batrox, Baxolex, Belfactrin, Belfactrin F, Bencole, Benectrin, Benectrin F, Berlocid, Bestofens, Bethaprim, Bethaprim DS, Bibakrim, Bicotrim, Bimatrim, Biogenerics Cotrimoxazole, Bioprim, Biosulten, Biotran, Biotrim, Biotrin, Biprim, Biseptin, Biseptol, Biseptrim, Bismoral, Bisultrim, Bitrim, Blexon, Boie Cotrimoxazole, Boschtrim, Brifeseptol, Broncoflam, Brongenit, BS, Canprim, Caretran, Centrim, Chemitrim, Chemix, Chemizol, Chemoprim, Chemotran, Chemotrim, Chemotrin, Chemozole, Chromo-Z, Cidaprim, Cipaprim, Ciplin, Ciplin DS, Citrim, Cladon, Clinitran, Clonea, Clotrizol, CM Trimeth S / Meth, CO-Sultrin, CO-Tasian, CO-Traisole 480, CO-Trim-Tablinen, CO-Trimazole, CO-Trimed, CO-Trimed D / S, CO-Trimoxa, CO-Trimoxazol A, CO-Trimoxazole DS, CO-Trimoxazole Pharmaniaga, CO-Trimoxazol FLX, Cobact, Cobal ST, Cocydal, Cofatrim, Colitran, Colizole, Colotrim, Comax, Comazole, Comazole N, Combact, Combi-Methoxan, Comixco, Comox, Comoxol, Contrimoxazole, Coprim, Coprime, Cosat, Cosig, Costazole, Cosulf, Cotoram, Cotran, Cotrazen, Cotrexel, Cotri, Cotribase, Cotribene, Cotribid, Cotril, Cotril Forte, Cotrilin, Cotrim, Cotrim-CT, Cotrim-Puren, Cotrim-Sandoz, Cotrim ABZ, Cotrimax, Cotrimaxazol, Cotrimaxazole, Cotrim Diolan, Cotrim E, Cotrimel, Cotrim Forte, Cotrim Forte EU RHO, Cotrim Hefa, Cotrimhexal, Cotrim Holsten Saft, Cotrimol, Cotrimox, Cotrimoxazol, Cotrimoxazol-Cophar, Cotrimoxazol AL, Cotrimoxazole, CO Trimoxazole COX, CO Trimoxazole KNT, Cotrimoxazole Ratiopharm, Cotrimoxazole RPG, Cotrimoxazol Genericon Pharma, Cotrimoxazol Richet Forte, Cotrimoxazol Vatch, Cotrimoxin, Cotrimox Wolff, Cotrimstada, Cotripharm, Cotrisul, Cotrixyl-L, Cotrizol, Cotrizol-G, Cotrizole, Cots, Cozol, Cozole, Creptrim, Curaprim, Daiphen, Decatrim, Deotrim, Dertrin, Dhatrin, Dino-BAC, Diseptyl, Diseptyl Forte, DLI Cotrimoxazole, Doctrim, Dosatran, Drilozole, Drossul, Droxol, Drylin, Dubac, Dumotrim, Duobact, Duobiocin, Duoctrin, DUO Septol, Duratrimet, Dutran, Dvaseptol, Dynaprim, Ectaprim, Ectaprim F, Ectrin, Editrim, Eduprim, Eliprim, Eroprim, Erotrim, Erphatrim, Esbesul, Escoprim, Espectrin, Espectroprima, Ethitrim, Eurotrim, Eusaprim, Eutrim, Exazol, Fabubac, Fakzol, Falprim, Fameprim, Fectrim, Fedimed, Fisat, Flatran, Flocot, Forcrim, Forteprim, G-Cotrimoxazole, Gamactrin, Gatrima, Genoctrin, Genoxzole, Gentrim, Genzaprim, Getrim, Globaxol, Gobens Trim, Graprima, Groseptol, Gunametrim, Hatrix, Helm Cotrimoxazole, Helveprim, Herixina, Hexaprim, Hicot, Hufacid, Huma-Trimel, Ibtrim, Imcotran, Imexim, Inatrim, Infatrim, Infectran, Infectrim, Infectrin, Infectrin F, Infesin, Intrafort, Introcin, Irgagen, Isoprim, Isotrim, Japtrim, Jasotrim, Jenamoxazol, Jestrim, Justeprim, K.B.famate, Kaftrim, Kathrex, Katrim, Kaytran, Kemocid, Kemoprim, Kentricid, Kepinol, Kindoprim, KO-Kure, Kombina, Kotazol, Kotrimoksazol, Krobactrol, L-Trim, Lacreozole, Lafayette Cotrimoxazole, Lagatrim, Lapikot, Laratrim, Larprim, Lastrim, Leotrim, Leprim, Lescot, Letus, Lictora, Lifactrin, Lifzol, Lisaprin, Litrim, Lobact, Longasal, Lupectrin, Lusaprim, Lykaprim, M-Moxa, M-Trim, Macprim, Macromed, Mactran, Madroxin, Maktrim, Martiprim, Maxaprim, Maxiprim, Maxitrin, Maxitrin-C, Maxol, Maxtrim, Maxzol, Mazatrim, Mebryn, Medcotrim, Medic AID Cotrimoxazole, Mediprim, Meditran, Meditrim, Medtrim, Megabroncoflam, Megaset, Megatrim, Meprim, Meprotrin, Merck-CO-Trimoxazol, Methoprim, Methotrin, Metoprim, Metoprin, Metoxiprim, Metrim, Metrim-F, Metrim-H, Metxaprim, Mexaprim, Mexazole, Mezenol, Micinovo, Micogyl, Micro-Cotrimoxazol, Microbid, Microbid DS, Microcetim, Micro CO-Trimoxazole, Microdyn, Microsupos Amigdalar, Microtrim, Mikotrim, Mikrosid, Miratrim, Moly, Mortin, Moxadden, Moxalas, Moxatrim, Moxzole, Mukadryl, Myctrim, Naftran, Napatrim, Navatrim, Necorzole, Neoset, Neotrim, Netocur, Neuroprim, Nicotrim, Nilium, Nodilon, Nopil, Norisep, Nortrim, Nortrime, Notrim, Notrime, Novactil, Novidrine, Novotrimel, Novotrimel DS, Novotrimox, Novotrim Plus, Novozole, NU-Cotrimox, NU-Cotrimox DS, Nucotrim, Nufaprim, NUO DE FEI, Nuruzole, Octil-S, Octran, Octrim, Oecotrim, Okatrim, Omegtrim, Omnatrim, Omsat, Onetrim, Oradin, Orbak, Orgastran, Oribact, Ormoprim, Ostrin Forte, Otrim, Ottoprim, Oxaprim, Pakzole, Pantrim, Patrim, Pehatrim, Penetrin, Pentrin, Penzole, Pharex CO-Trimoxazole, Pharmatrim, Pharmazol, Phartex, Pisatrina, Plurisul, Polibatrin, Politrim, Polytran, Pribac, Primadex, Primasul, Primasulf, Primatrim, Primavon, Primazol, Primazole, Primazol Sterkar, Primotren, Primox, Primsulfon, Primzole, Protrin, Protrin DF, Pulkrin, Purbac, Q-MED CO-Trimoxazole, Qiftrim, Qiftrin, Quimio-PED, Quisulyn, Rancotrim, Rasat, Raseptol, Ratrim, Regtin, Rematrim, Renatrim, Resprim, Resprim M, Retrim, Rexaprim, Ribatrim, Rimazole, Rimezone, Riva-SEP DS, Rivoprim, Rizol, Rolab-CO-Trimoxazole, Rolprim, Roubac, Roxtrim, Roytrin, Salgatran, Saltrim, Sanprima, Saptrim, Satrim, Sbpa Trimeth Smeth, Scribcin, Seematrim, Seftrim, Selectrin, Semozol, Sepiran, Sepmax, Septabid, Septabid-2, Septazol, Septazole, Septerin, Septinix, Septiolan, Septocid R +, Septoprin, Septra, Septra DS, Septran, Septrin-S, Septrin Paediatric, Servitrim, Servitrim-F, Sigaprim, Sigatrim, Silpin, Siltran, Sinatrim, Sinersul, Sinotrim, Sisoprim, Sistrim, Sitrim, Skytrin, Smartrim, SMX / TMP, SMZ ( CO ), SMZ-TMP, SMZ-TMP DS, Soltrim, Soltrim F, Soptrim, Sosetran, Spectrem, Spectrim, Stan, Stopan, Strim, Suftrex, Sulbacta, Sulfa 100 + Trim 20, Sulfa 200 + Trima 40, Sulfa 400 + Trima 80, Sulfa 800 + Trima 160, Sulfagrand, Sulfamer, Sulfamet, Sulfamethoprim, Sulfamethoxazole and Trimethoprim, Sulfamethoxazole C, Sulfamethoxazole / Trimethoprim, Sulfamethoxazole with Trimethoprim, Sulfametosazol CON Trimetoprim, Sulfametoxazol, Sulfametoxazol / Trimetoprim, Sulfametoxazol MED Trimetoprim, Sulfametoxazol MED Trimetoprim SAD, Sulfametoxazol + Trimetoprima, Sulfametoxazol Y Trimetoprima MF, Sulfaprim, Sulfarim, Sulfatalpin, Sulfaton, Sulfatrim, Sulfatrim DS, Sulfatropim, Sulfawal-T, Sulfinam, Sulfinam S, Sulfoid Trimetho, Sulfometh, Sulfonamide, Sulfort, Sulfotrim, Sulfotrimin, Sulfotrim PED, Sulftran, Sulgotri, Sulotrim, Sulotrim Forte, Sulphaprim, Sulphathoprim, Sulphatran, Sulphatrim, Sulphax, Sulphytrim Forte, Sulphytrim Junior, Sulprim, Sulprimed, Sultase, Sulthrim, Sulthrim-F, Sultiprim, Sultorim, Sultra, Sultrex, Sultrim, Sultrima, Sultrimmix, Sultrivon-F, Sultropim, Sumetoprim, Sumetrolim, Sumetrolin, Sumitran, Suntrim, Supim, Supracombin, Suprasulf, Suprex, Supribac, Supribac F, Suprim, Suprimass, Suprin, Suptrex, Suptrim, Sutaprim, Sutrim, Sutrisan, Suxprim, Syltrifil, Synac, Synastat, Synbac, Synco-Smzt, Syndal, Synermed, Synerzole, Synetra, Synotrim, Syntoprim, System, T.S, Tabrol, Tagremin, Teof, Terasulf, Terbosulfa, Teutrin, Theraprim, Therasept, Theratrim, Thoprim, Thriazol, Thriazol-S, TMP-SMX, TMS, Torrid, Tprim, Trelibec, Trib, Trib DS, Tricban, Tricomox, Tricot, Trifides, Triforam, Trihexal, Trim, Trim-S, Trim. Comp., Trima, Trimaxazole, Trimel, Trimephar, Trimeran, Trimerazin, Trimeril, Trimesol, Trimesul, Trimesulf, Trimesulf-F, Trimeta, Trimethoprim Comp., Trimethoprim Sulfa, Trimethoprim Sulfamethoxazole, Trimethox, Trimetoger, Trimetop Duplo, Trimetoprim-Sulfa GEA, Trimetoprima, Trimetoprima CON Sulfametoxazol, Trimetoprim + Sulfametoxazol, Trimetoprim Sulfa, Trimetoprim Sulfa Genfar, Trimetoprim Sulfametoxazol, Trimetoprim Sulfametoxazol MK, Trimetoprim with Sulfametoxazol, Trimetoprin Sulfa, Trimetotal, Trimetox, Trimetrin, Trimetsol, Trimexasol, Trimexazol, Trimexazole, Trimexole-F, Trimezol, Trimezole, Trimfasul, Trimidar M, Triminex, Trimocom, Trimoks, Trimosul, Trimosulfa, Trimoxavin, Trimoxazol, Trimoxazole-BC, Trimoxin, Trimoxis, Trimoxsul, Trimozol, Trimsul, Trimzol, Triphimox, Tripur, Trisep, Trisfides, Trisolak Forte, Trisolvat, Trisul, Trisulcom, Trisulfa, Trisulfa F, Trisulfose, Trisuprim, Trisural, Tritenk, Tritenk Forte, Tritosul, Tritosul F, Trixazol, Trixazol Fort, Trixzol, Trizole, Tryseptolum, TW Trimeth S / Meth, Tytrim, U-Prin, Ulfaprim, Ultrasept, Ultrazole, Ultrim, Unitran, Uprina, Urethrax, Urodown, Uroplus DS, Urtium, Utrin, Versatrim, Virin, Weiditrin, Wiatrim, Wiltran, Wypal, X-Trim, XA-Zole, Xazotrim, Xepaprim, Xerazole, Xeroprim, Yekaprim, Zactron, Zamboprim, Zantran, Zaxol, Zecatrim, Zeptra, Zerrprim, Zolebid, Zolmed, Zoltrijem, Zoltrim, Zultrop