Difference between revisions of "Fostamatinib (Tavalisse)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Spleen tyrosine kinase (SYK) inhibitor. The main metabolite of fostamatinib is R406, which reduces antibody-mediated destruction of platelets. R406 also inhibits signal transduction of Fc-activating receptors and B-cell receptor.<ref name=insert>[http://tavalisse.com/downloads/pdf/Full-Prescribing-Information.pdf Fostamatinib (Tavalisse) package insert]</ref><ref>[[Media:Fostamatinib.pdf | Fostamatinib (Tavalisse) package insert (locally hosted backup)]]</ref><ref>[http://tavalisse.com/ Tavalisse manufacturer's website]</ref> | + | Class/mechanism: Spleen tyrosine kinase (SYK) inhibitor. The main metabolite of fostamatinib is R406, which reduces antibody-mediated destruction of platelets. R406 also inhibits signal transduction of Fc-activating receptors and B-cell receptor.<ref name=insert>[http://tavalisse.com/downloads/pdf/Full-Prescribing-Information.pdf Fostamatinib (Tavalisse) package insert]</ref><ref>[[Media:Fostamatinib.pdf | Fostamatinib (Tavalisse) package insert (locally hosted backup)]]</ref><ref>[http://tavalisse.com/ Tavalisse manufacturer's website]</ref><ref>Podolanczuk A, Lazarus AH, Crow AR, Grossbard E, Bussel JB. Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk. Blood. 2009 Apr 2;113(14):3154-60. [http://www.bloodjournal.org/content/113/14/3154 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/19096013 PubMed]</ref><ref>Fostamatinib for persistent/chronic adult immune thrombocytopenia. Newland A, Lee EJ, McDonald V, Bussel JB. Immunotherapy. 2018 Jan;10(1):9-25. [https://www.futuremedicine.com/doi/10.2217/imt-2017-0097?url_ver=Z39.88-2003 link to original article] [https://www.ncbi.nlm.nih.gov/pubmed/28967793 PubMed]</ref> |
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<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
Revision as of 11:47, 19 April 2018
General information
Class/mechanism: Spleen tyrosine kinase (SYK) inhibitor. The main metabolite of fostamatinib is R406, which reduces antibody-mediated destruction of platelets. R406 also inhibits signal transduction of Fc-activating receptors and B-cell receptor.[1][2][3][4][5]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Preliminary data
Diffuse large B-cell lymphoma; Follicular lymphoma
- Friedberg JW, Sharman J, Sweetenham J, Johnston PB, Vose JM, Lacasce A, Schaefer-Cutillo J, De Vos S, Sinha R, Leonard JP, Cripe LD, Gregory SA, Sterba MP, Lowe AM, Levy R, Shipp MA. Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia. Blood. 2010 Apr 1;115(13):2578-85. Epub 2009 Nov 17. link to original article PubMed
Patient drug information
History of changes in FDA indication
- 4/17/2018: Granted FDA regular approval "for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment."
Also known as
- Code names: R788, R935788
References
- ↑ 1.0 1.1 1.2 Fostamatinib (Tavalisse) package insert
- ↑ Fostamatinib (Tavalisse) package insert (locally hosted backup)
- ↑ Tavalisse manufacturer's website
- ↑ Podolanczuk A, Lazarus AH, Crow AR, Grossbard E, Bussel JB. Of mice and men: an open-label pilot study for treatment of immune thrombocytopenic purpura by an inhibitor of Syk. Blood. 2009 Apr 2;113(14):3154-60. link to original article PubMed
- ↑ Fostamatinib for persistent/chronic adult immune thrombocytopenia. Newland A, Lee EJ, McDonald V, Bussel JB. Immunotherapy. 2018 Jan;10(1):9-25. link to original article PubMed