Difference between revisions of "Melphalan (Alkeran)"
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==Diseases for which it is used== | ==Diseases for which it is used== | ||
*[[Acute promyelocytic leukemia]] | *[[Acute promyelocytic leukemia]] | ||
| − | *[[ | + | *[[CNS lymphoma]] |
| + | *[[Diffuse large B-cell lymphoma]] | ||
| + | *[[Ewing's sarcoma]] | ||
| + | *[[Follicular lymphoma]] | ||
| + | *[[HIV-associated lymphoma]] | ||
*[[Hodgkin lymphoma]] | *[[Hodgkin lymphoma]] | ||
*[[Light-chain (AL) amyloidosis]] | *[[Light-chain (AL) amyloidosis]] | ||
| + | *[[Mantle cell lymphoma]] | ||
*[[Multiple myeloma]] | *[[Multiple myeloma]] | ||
*[[Plasma cell leukemia]] | *[[Plasma cell leukemia]] | ||
| − | |||
==Patient drug information== | ==Patient drug information== | ||
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==Also known as== | ==Also known as== | ||
| − | + | *'''Generic names:''' L-PAM, L-Sacrolysin, L-Sarcolysin, phenylalanine mustard | |
| − | + | *'''Brand names:''' Alkeran, Alkerana, Levofolan, Melfalan | |
| − | |||
| − | |||
| − | |||
| − | |||
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==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
| − | |||
[[Category:Intravenous medications]] | [[Category:Intravenous medications]] | ||
| + | [[Category:Oral medications]] | ||
| + | |||
[[Category:Irritant chemotherapy]] | [[Category:Irritant chemotherapy]] | ||
[[Category:Neutral chemotherapy]] | [[Category:Neutral chemotherapy]] | ||
| − | |||
[[Category:Alkylating agents]] | [[Category:Alkylating agents]] | ||
| Line 51: | Line 44: | ||
[[Category:Acute promyelocytic leukemia medications]] | [[Category:Acute promyelocytic leukemia medications]] | ||
| − | [[Category: | + | [[Category:CNS lymphoma medications]] |
| + | [[Category:Diffuse large B-cell lymphoma medications]] | ||
| + | [[Category:Ewing's sarcoma medications]] | ||
| + | [[Category:Follicular lymphoma medications]] | ||
| + | [[Category:HIV-associated lymphoma medications]] | ||
[[Category:Hodgkin lymphoma medications]] | [[Category:Hodgkin lymphoma medications]] | ||
[[Category:Light-chain (AL) amyloidosis medications]] | [[Category:Light-chain (AL) amyloidosis medications]] | ||
| + | [[Category:Mantle cell lymphoma medications]] | ||
[[Category:Multiple myeloma medications]] | [[Category:Multiple myeloma medications]] | ||
[[Category:Plasma cell leukemia medications]] | [[Category:Plasma cell leukemia medications]] | ||
| − | |||
[[Category:Drugs FDA approved in 1964]] | [[Category:Drugs FDA approved in 1964]] | ||
Revision as of 01:42, 28 January 2018
General information
Class/mechanism: Nitrogen mustard, alkylator. Melphalan is a bischloroethylamine alkylating agent that crosslinks DNA by binding at the N7 position of guanine, with activity against resting and proliferating cells.[1][2]
Route: IV, PO
Extravasation: irritant or neutral, depending on reference
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute promyelocytic leukemia
- CNS lymphoma
- Diffuse large B-cell lymphoma
- Ewing's sarcoma
- Follicular lymphoma
- HIV-associated lymphoma
- Hodgkin lymphoma
- Light-chain (AL) amyloidosis
- Mantle cell lymphoma
- Multiple myeloma
- Plasma cell leukemia
Patient drug information
- Melphalan (Alkeran) patient drug information (Chemocare)[3]
- Melphalan (Alkeran) patient drug information (UpToDate)[4]
History of changes in FDA indication
- 1/17/1964: Initial FDA approval[5]
Also known as
- Generic names: L-PAM, L-Sacrolysin, L-Sarcolysin, phenylalanine mustard
- Brand names: Alkeran, Alkerana, Levofolan, Melfalan
References
Categories:
- Drug index
- Intravenous medications
- Oral medications
- Irritant chemotherapy
- Neutral chemotherapy
- Alkylating agents
- Nitrogen mustards
- Acute promyelocytic leukemia medications
- CNS lymphoma medications
- Diffuse large B-cell lymphoma medications
- Ewing's sarcoma medications
- Follicular lymphoma medications
- HIV-associated lymphoma medications
- Hodgkin lymphoma medications
- Light-chain (AL) amyloidosis medications
- Mantle cell lymphoma medications
- Multiple myeloma medications
- Plasma cell leukemia medications
- Drugs FDA approved in 1964