Difference between revisions of "Leucovorin (Folinic acid)"

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*[[Cervical cancer]] ‎  
 
*[[Cervical cancer]] ‎  
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*[[Cholangiocarcinoma]]
 
*[[Colon cancer]] ‎
 
*[[Colon cancer]] ‎
 
*[[Esophageal cancer]] ‎  
 
*[[Esophageal cancer]] ‎  
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!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 
!colspan="8" align="center" style="background-color:#0066FF"| '''Synonyms'''
 
|-
 
|-
−
|Abic Leucovorin
 
−
|AC.folinico GI
 
−
|AI JIE Kang
 
 
|Antrex
 
|Antrex
 
|Asovorin
 
|Asovorin
 
|Biovorin
 
|Biovorin
−
|BO Sheng
 
 
|Buateron
 
|Buateron
−
|-
 
 
|Calcifolin
 
|Calcifolin
 
|Calcio Folinato
 
|Calcio Folinato
 
|Calciumfolin
 
|Calciumfolin
 
|Calciumfolinat
 
|Calciumfolinat
−
|Calciumfolinat-GRY
 
−
|Calciumfolinat Ebewe
 
−
|Calciumfolinat Hexal
 
−
|Calciumfolinat Mayne
 
 
|-
 
|-
 
|Calcium Folinato
 
|Calcium Folinato
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|Folaxin
 
|Folaxin
 
|Foliben
 
|Foliben
−
|Folic Acid Roche
+
|Foli Cell
 
|-
 
|-
−
|Foli Cell
 
 
|Folidan
 
|Folidan
 
|Folidar
 
|Folidar
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|Folinac
 
|Folinac
 
|Folinate Calcium
 
|Folinate Calcium
−
|Folinate DE Calcium Aguettant
 
−
|Folinate DE Calcium Dakota Pharm
 
−
|-
 
 
|Folinato
 
|Folinato
−
|Folinato Calcico
 
−
|Folinato Calcico Ferrer
 
−
|Folinato DE Calcio
 
 
|Folinfabra
 
|Folinfabra
 
|Folinoral
 
|Folinoral
 +
|-
 
|Folinoxan
 
|Folinoxan
 
|Folinvit
 
|Folinvit
−
|-
 
 
|Foliplus
 
|Foliplus
 
|Folmigor
 
|Folmigor
−
|FU LI Neng
 
 
|Ifavor
 
|Ifavor
 
|Isovorin
 
|Isovorin
 
|Kalciumfolinat Perivita
 
|Kalciumfolinat Perivita
 
|Kalsiumfolinat
 
|Kalsiumfolinat
 +
|-
 
|Kunyrin
 
|Kunyrin
−
|-
 
 
|Lederfolat
 
|Lederfolat
 
|Lederfolin
 
|Lederfolin
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|Legifol
 
|Legifol
 
|Leucocalcin
 
|Leucocalcin
−
|Leuconolver,Leucovorin
 
 
|-
 
|-
 +
|Leuconolver
 
|Leucovorina
 
|Leucovorina
−
|Leucovorina Calcica
 
−
|Leucovorina Calcica Teva
 
−
|Leucovorina Calcico
 
−
|Leucovorina Delta Farma
 
−
|Leucovorina Filaxis
 
−
|Leucovorina Raffo
 
−
|Leucovorina Richet
 
−
|-
 
−
|Leucovorina Servycal
 
−
|Leucovorin CA
 
−
|Leucovorin Calcium
 
−
|Leucovorin Calcium Farmos
 
−
|Leucovorin Dabur
 
 
|Leucovorine
 
|Leucovorine
−
|Leucovorine Calcium
 
−
|Leucovorin Lens
 
−
|-
 
−
|Leucovorin Teva
 
 
|Leukovorin
 
|Leukovorin
 
|Lovorin
 
|Lovorin
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|Medifolin
 
|Medifolin
 
|Medsavorina
 
|Medsavorina
 +
|-
 
|Neofolin
 
|Neofolin
 
|Nyrin
 
|Nyrin
−
|-
 
 
|O Folin
 
|O Folin
 
|Osfolate
 
|Osfolate
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|Prefolic
 
|Prefolic
 
|Prevax
 
|Prevax
 +
|-
 
|Recovorin
 
|Recovorin
 
|Reotan
 
|Reotan
−
|-
 
 
|Rescuvolin
 
|Rescuvolin
 
|Resfolin
 
|Resfolin
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|Rontafor
 
|Rontafor
 
|Sanifolin
 
|Sanifolin
−
|SHI Ming
 
 
|Sodium Folinate
 
|Sodium Folinate
 +
|-
 
|Tecnovorin
 
|Tecnovorin
−
|-
 
−
|Tong AO
 
 
|Tonofolin
 
|Tonofolin
 
|Veravorin
 
|Veravorin
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[[Category:Cervical cancer medications]]
 
[[Category:Cervical cancer medications]]
 +
[[Category:Cholangiocarcinoma medications]]
 
[[Category:Colon cancer medications]]
 
[[Category:Colon cancer medications]]
 
[[Category:Esophageal cancer medications]]
 
[[Category:Esophageal cancer medications]]

Revision as of 01:57, 23 January 2018

General information

Class/mechanism: Folic acid analog; counteracts the effects of folic acid antagonists such as methotrexate, which acts by inhibiting dihydrofolate reductase. Enhances the activity of Fluorouracil (5-FU) by inhibiting thymidylate synthase.[1][2]
Route: PO, IM, IV
Extravasation: no information

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Diseases for which it is used

Note: these are diseases where folinic acid is used as an adjuvant to Fluorouracil (5-FU), as opposed to an antidote as it is used in conjunction with Methotrexate (MTX)

Patient drug information

History of changes in FDA indication

  • 6/20/1952: Initial FDA approval

Also known as

Synonyms
Antrex Asovorin Biovorin Buateron Calcifolin Calcio Folinato Calciumfolin Calciumfolinat
Calcium Folinato Calcium Folint Calcium Leucovorin Calcium Leucovorn Calcivoran Calc Leucovorn Calfolex Calfolin
Calinat Cehafolin Citofolin Citrovorum Factor Claro Cromatonbic Folinico Dalisol Degalin
Divifolin Durofolin Ecofol Elvefocal Emovis Erbanfol Estroquin Fastovorin
Fauldleuco Fayining Fedolen Ferbon Folaren Folaxin Foliben Foli Cell
Folidan Folidar Foliment Folinac Folinate Calcium Folinato Folinfabra Folinoral
Folinoxan Folinvit Foliplus Folmigor Ifavor Isovorin Kalciumfolinat Perivita Kalsiumfolinat
Kunyrin Lederfolat Lederfolin Lederfoline Lederle Leucovorin Ledervorin Legifol Leucocalcin
Leuconolver Leucovorina Leucovorine Leukovorin Lovorin Medicofolin Medifolin Medsavorina
Neofolin Nyrin O Folin Osfolate Osfolato Perfolate Prefolic Prevax
Recovorin Reotan Rescuvolin Resfolin Ribofolin Rontafor Sanifolin Sodium Folinate
Tecnovorin Tonofolin Veravorin Vorina Wellcovorin Zyofolin Zytofolin

References

  1. ↑ 1.0 1.1 Folinic acid (Leucovorin) package insert
  2. ↑ Folinic acid (Leucovorin) package insert (locally hosted backup)
  3. ↑ Folinic acid (Leucovorin) patient drug information (Chemocare)
  4. ↑ Folinic acid (Leucovorin) patient drug information (UpToDate)
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