Levels of Evidence

The purpose of this page is to create a reference to describe our methodology for assigning levels of evidence to regimens. We have taken a simplified approach to rating evidence, based on a three-color metric (red/yellow/green). Of course, there are finer gradations of the quality of evidence so this simplified scheme should be taken with a grain of salt.

We are currently collaborating on this list, which is a work in progress. Criteria that may be considered:

• Phase: I, II, III, IV
• Interventional/observational
  • Cohort
  • Case-control
  • Cross-sectional study
  • Ecological study
• Prospective/retrospective
• Randomized, blind (single/double)
• Compared against: placebo, standard of care
• Superiority, non-inferiority, equivalence
• Outcomes:
  • Overall survival
  • Progression-free survival (PFS), disease-free survival (DFS)
  • Quality of life/toxicity
  • RECIST: Complete response, partial response, stable disease
  • Complete/major molecular response (CMR, MMR), complete/major cytogenetic response (CCR/CCyR, MCR/MCyR), complete/partial hematologic response (CHR, PHR)
• Number of sites (single, regional, national, international)
• Number of experimental arms

Colors to be used: Green box text Yellow box text Red box text