Difference between revisions of "Dactinomycin (Cosmegen)"
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| + | Also known as Actinomycin or Actinomycin D. | ||
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==General information== | ==General information== | ||
| − | Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050682s025lbl.pdf Dactinomycin (Cosmegen) package insert]</ref><ref>[ | + | Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2009/050682s025lbl.pdf Dactinomycin (Cosmegen) package insert]</ref><ref>[[Media:Dactinomycin.pdf | Dactinomycin (Cosmegen) package insert (locally hosted backup)]]</ref> |
<br>Route: IV | <br>Route: IV | ||
<br>Extravasation: [[vesicant]] | <br>Extravasation: [[vesicant]] | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Bone cancer]] | ||
| + | *[[Uterine cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http:// | + | *[http://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/dactinomycin.aspx Dactinomycin (Cosmegen) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/dactinomycin-patient-drug-information Dactinomycin (Cosmegen) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Vesicant chemotherapy]] | ||
| + | [[Category:DNA synthesis inhibitors]] | ||
| + | [[Category:Bone cancer medications]] | ||
| + | [[Category:Uterine cancer medications]] | ||
Revision as of 05:32, 14 October 2012
Also known as Actinomycin or Actinomycin D.
General information
Class/mechanism: Antibiotic oncologic, intercalates between guanine and cytosine DNA base pairs, inhibiting DNA and RNA synthesis.[1][2]
Route: IV
Extravasation: vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Dactinomycin (Cosmegen) patient drug information (Chemocare)[3]
- Dactinomycin (Cosmegen) patient drug information (UpToDate)[4]