Difference between revisions of "Cyclophosphamide (Cytoxan)"
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| + | Also known as cytophosphane, Endoxan, Neosar, Procytox, or Revimmune. | ||
| + | |||
==General information== | ==General information== | ||
| − | Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[ | + | Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.<ref name="insert">[http://packageinserts.bms.com/pi/pi_cytoxan.pdf Cyclophosphamide (Cytoxan) package insert]</ref><ref>[[Media:Cyclophosphamide.pdf | Cyclophosphamide (Cytoxan) package insert (locally hosted backup)]]</ref> |
<br>Route: IV, PO | <br>Route: IV, PO | ||
<br>Extravasation: no information, n/a | <br>Extravasation: no information, n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute lymphocytic leukemia]] | ||
| + | *[[Bone cancer]] | ||
| + | *[[Breast cancer]] | ||
| + | *[[Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)]] | ||
| + | *[[Hodgkin lymphoma]] | ||
| + | *[[Multiple myeloma]] | ||
| + | *[[Non-Hodgkin lymphoma]] | ||
| + | *[[Thymoma]] | ||
| + | *[[Transplant conditioning regimens]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/cyclophosphamide.aspx Cyclophosphamide (Cytoxan) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/cyclophosphamide.aspx Cyclophosphamide (Cytoxan) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/cyclophosphamide-patient-drug-information Cyclophosphamide (Cytoxan) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cyclophosphamide-patient-drug-information Cyclophosphamide (Cytoxan) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/cyclophosphamide-patient-drug-information Cyclophosphamide (Cytoxan) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/cyclophosphamide-patient-drug-information Cyclophosphamide (Cytoxan) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Alkylating agents]] | ||
| + | [[Category:Acute lymphocytic leukemia medications]] | ||
| + | [[Category:Bone cancer medications]] | ||
| + | [[Category:Breast cancer medications]] | ||
| + | [[Category:Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications]] | ||
| + | [[Category:Hodgkin lymphoma medications]] | ||
| + | [[Category:Multiple myeloma medications]] | ||
| + | [[Category:Non-Hodgkin lymphoma medications]] | ||
| + | [[Category:Thymoma medications]] | ||
| + | [[Category:Transplant medications]] | ||
Revision as of 06:10, 13 October 2012
Also known as cytophosphane, Endoxan, Neosar, Procytox, or Revimmune.
General information
Class/mechanism: Alkylating agent; transformed primarily in the liver to active metabolites which alkylate and crosslink DNA.[1][2]
Route: IV, PO
Extravasation: no information, n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Acute lymphocytic leukemia
- Bone cancer
- Breast cancer
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL)
- Hodgkin lymphoma
- Multiple myeloma
- Non-Hodgkin lymphoma
- Thymoma
- Transplant conditioning regimens
Patient drug information
- Cyclophosphamide (Cytoxan) patient drug information (Chemocare)[3]
- Cyclophosphamide (Cytoxan) patient drug information (UpToDate)[4]
References
Categories:
- Drug index
- Chemotherapy
- Alkylating agents
- Acute lymphocytic leukemia medications
- Bone cancer medications
- Breast cancer medications
- Chronic lymphocytic leukemia (CLL) and Small lymphocytic lymphoma (SLL) medications
- Hodgkin lymphoma medications
- Multiple myeloma medications
- Non-Hodgkin lymphoma medications
- Thymoma medications
- Transplant medications