Difference between revisions of "Crizotinib (Xalkori)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Tyrosine kinase inhibitor; inhibits anaplastic lymphoma kinase (ALK), c-MET and subsequent expression of Hepatocyte Growth Factor Receptor (HGFR), and Recepteur d’Origine Nantais (RON). Inhibits activity of fusion proteins involving ALK, such as EML4-ALK and NPM-ALK.<ref name="insert">[http://labeling.pfizer.com/showlabeling.aspx?id=676 Crizotinib (Xalkori) package insert]</ref><ref>[ | + | Class/mechanism: Tyrosine kinase inhibitor; inhibits anaplastic lymphoma kinase (ALK), c-MET and subsequent expression of Hepatocyte Growth Factor Receptor (HGFR), and Recepteur d’Origine Nantais (RON). Inhibits activity of fusion proteins involving ALK, such as EML4-ALK and NPM-ALK.<ref name="insert">[http://labeling.pfizer.com/showlabeling.aspx?id=676 Crizotinib (Xalkori) package insert]</ref><ref>[[Media:Crizotinib.pdf | Crizotinib (Xalkori) package insert (locally hosted backup)]]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Non-small cell lung cancer]] | ||
==Patient drug information== | ==Patient drug information== | ||
| + | *[http://labeling.pfizer.com/showlabeling.aspx?id=676#page=15 Crizotinib (Xalkori) package insert pages 15-18]<ref name="insert"></ref> | ||
| + | *[http://chemocare.com/chemotherapy/drug-info/crizotinib.aspx Crizotinib (Xalkori) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/crizotinib.aspx Crizotinib (Xalkori) patient drug information (Chemocare)]</ref> | ||
*[http://www.uptodate.com/contents/crizotinib-patient-drug-information Crizotinib (Xalkori) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/crizotinib-patient-drug-information Crizotinib (Xalkori) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/crizotinib-patient-drug-information Crizotinib (Xalkori) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/crizotinib-patient-drug-information Crizotinib (Xalkori) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
| + | |||
| + | [[Category:Drug index]] | ||
| + | [[Category:Chemotherapy]] | ||
| + | [[Category:Tyrosine kinase inhibitors]] | ||
| + | [[Category:ALK inhibitors]] | ||
Revision as of 15:59, 8 October 2012
General information
Class/mechanism: Tyrosine kinase inhibitor; inhibits anaplastic lymphoma kinase (ALK), c-MET and subsequent expression of Hepatocyte Growth Factor Receptor (HGFR), and Recepteur d’Origine Nantais (RON). Inhibits activity of fusion proteins involving ALK, such as EML4-ALK and NPM-ALK.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Crizotinib (Xalkori) package insert pages 15-18[1]
- Crizotinib (Xalkori) patient drug information (Chemocare)[3]
- Crizotinib (Xalkori) patient drug information (UpToDate)[4]