Difference between revisions of "Ibritumomab tiuxetan (Zevalin)"
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<br>Extravasation: potential [[vesicant]] | <br>Extravasation: potential [[vesicant]] | ||
− | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. | + | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> |
==Diseases for which it is used== | ==Diseases for which it is used== |
Revision as of 15:11, 3 December 2017
General information
Class/mechanism: Anti-CD20 antibody chelated by tiuxetan to a radioactive agent (Y-90, yttrium-90; or In-111, indium-111). Y-90 emits beta radiation, which causes cellular damage via free radicals. This results in damage to cells which express the CD20 antigen (human B-lymphocyte-restricted differentiation antigen, Bp35).[1][2][3]
Route: IV
Extravasation: potential vesicant
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
- Diffuse large B-cell lymphoma
- Follicular lymphoma
- Mantle cell lymphoma
- Marginal zone lymphoma
- Transplant conditioning regimens
Patient drug information
- Ibritumomab tiuxetan (Zevalin) patient drug information (Chemocare)[4]
- Ibritumomab tiuxetan (Zevalin) patient drug information (UpToDate)[5]
History of changes in FDA indication
- 2/19/2002: Granted FDA accelerated approval for the treatment of patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma, including patients with Rituximab (Rituxan) refractory follicular non-Hodgkin’s lymphoma.
- 9/3/2009: Granted FDA full approval; label expanded for the treatment of previously untreated follicular NHL in patients who achieve a partial or complete response to first-line chemotherapy.
References
- Drug index
- Chemotherapy
- Intravenous medications
- Antibody medications
- Anti-CD20 antibodies
- Anti-CD20 medications
- Radioimmunotherapy
- Radioactive agents
- Diffuse large B-cell lymphoma medications
- Follicular lymphoma medications
- Mantle cell lymphoma medications
- Marginal zone lymphoma medications
- Transplant medications
- Drugs FDA approved in 2002