Difference between revisions of "Asparaginase (Elspar)"
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| − | Also known as L-asparaginase, asparaginase (E. coli). | + | Also known as L-asparaginase, asparaginase (E. coli), or Kidrolase. |
==General information== | ==General information== | ||
| − | Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.<ref name="insert">[http://www.lundbeck.com/upload/us/files/pdf/Products/Elspar_PI_US_EN.pdf Asparaginase (Elspar) package insert]</ref><ref>[ | + | Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.<ref name="insert">[http://www.lundbeck.com/upload/us/files/pdf/Products/Elspar_PI_US_EN.pdf Asparaginase (Elspar) package insert]</ref><ref>[[Media:Asparaginase.pdf | Asparaginase (Elspar) package insert (locally hosted backup)]]</ref> |
| − | <br>Route: IV | + | <br>Route: IV, IM |
<br>Extravasation: no information | <br>Extravasation: no information | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
| + | |||
| + | ==Diseases for which it is used== | ||
| + | *[[Acute lymphocytic leukemia]] | ||
==Patient drug information== | ==Patient drug information== | ||
| − | *[http://chemocare.com/ | + | *[http://chemocare.com/chemotherapy/drug-info/asparaginase.aspx Asparaginase (Elspar) patient drug information (Chemocare)]<ref>[http://chemocare.com/chemotherapy/drug-info/asparaginase.aspx Asparaginase (Elspar) patient drug information (Chemocare)]</ref> |
*[http://www.uptodate.com/contents/asparaginase-patient-drug-information Asparaginase (Elspar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/asparaginase-patient-drug-information Asparaginase (Elspar) patient drug information (UpToDate)]</ref> | *[http://www.uptodate.com/contents/asparaginase-patient-drug-information Asparaginase (Elspar) patient drug information (UpToDate)]<ref>[http://www.uptodate.com/contents/asparaginase-patient-drug-information Asparaginase (Elspar) patient drug information (UpToDate)]</ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 15:31, 7 October 2012
Also known as L-asparaginase, asparaginase (E. coli), or Kidrolase.
General information
Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.[1][2]
Route: IV, IM
Extravasation: no information
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Asparaginase (Elspar) patient drug information (Chemocare)[3]
- Asparaginase (Elspar) patient drug information (UpToDate)[4]