Difference between revisions of "All-trans retinoic acid (ATRA)"
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==General information== | ==General information== | ||
| − | Class/mechanism: Retinoid, induces maturation/differentiation of [[Acute myeloid leukemia|acute promyelocytic leukemia (APL)]] cells. Exact mechanism unknown.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20438s004lbl.pdf Tretinoin (Vesanoid) package insert]</ref><ref>[ | + | Class/mechanism: Retinoid, induces maturation/differentiation of [[Acute myeloid leukemia|acute promyelocytic leukemia (APL)]] cells. Exact mechanism unknown.<ref name="insert">[http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20438s004lbl.pdf Tretinoin (Vesanoid) package insert]</ref><ref>[[Media:Tretinoin.pdf | Tretinoin (Vesanoid) package insert (locally hosted backup)]]</ref> |
<br>Route: PO | <br>Route: PO | ||
<br>Extravasation: n/a | <br>Extravasation: n/a | ||
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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| + | ==Diseases for which it is used== | ||
| + | *[[Acute myeloid leukemia]] | ||
==Patient drug information== | ==Patient drug information== | ||
Revision as of 01:51, 7 October 2012
Also known as all-trans retinoic acid, or ATRA.
General information
Class/mechanism: Retinoid, induces maturation/differentiation of acute promyelocytic leukemia (APL) cells. Exact mechanism unknown.[1][2]
Route: PO
Extravasation: n/a
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Tretinoin (Vesanoid) patient drug information (Chemocare)[3]
- Tretinoin (Vesanoid) patient drug information (UpToDate)[4]