Difference between revisions of "Asparaginase (Elspar)"
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Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.<ref name="insert">[http://www.lundbeck.com/upload/us/files/pdf/Products/Elspar_PI_US_EN.pdf Asparaginase (Elspar) package insert]</ref><ref>[[Media:Asparaginase.pdf | Asparaginase (Elspar) package insert (locally hosted backup)]]</ref> | Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.<ref name="insert">[http://www.lundbeck.com/upload/us/files/pdf/Products/Elspar_PI_US_EN.pdf Asparaginase (Elspar) package insert]</ref><ref>[[Media:Asparaginase.pdf | Asparaginase (Elspar) package insert (locally hosted backup)]]</ref> | ||
<br>Route: IV, IM | <br>Route: IV, IM | ||
| − | <br>Extravasation: | + | <br>Extravasation: [[neutral]] |
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/elspar-l-asparaginase-342099 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as [http://www.thomsonhc.com/home/dispatch Micromedex], [http://online.lexi.com/ Lexicomp], [http://reference.medscape.com/drug/elspar-l-asparaginase-342099 Medscape], [http://www.utdol.com/online/content/search.do UpToDate (courtesy of Lexicomp)], or the prescribing information.<ref name="insert"></ref> | ||
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==Also known as== | ==Also known as== | ||
| − | Asparaginasa, Asparaginase Medac, Chephacardin, Colaspase, Crasnitin, Elspar, Erwina Asparaginas, Erwinase, Erwinaze, Erwinia, Erwiniase, Kidrolase, L-ASP, L-Asparaginasa Filaxis, Laspar, L Asparaginasa, L Asparaginase, L Asparaginasum, Leucoginase, Leunase, Paronal | + | Asparaginasa, Asparaginase Medac, Chephacardin, Colaspase, Crasnitin, Crisantaspase, Elspar, Erwina Asparaginas, Erwinase, Erwinaze, Erwinia, Erwiniase, Kidrolase, L-ASP, L-Asparaginasa Filaxis, Laspar, L Asparaginasa, L Asparaginase, L Asparaginasum, Leucoginase, Leunase, Paronal |
==References== | ==References== | ||
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[[Category:Drug index]] | [[Category:Drug index]] | ||
[[Category:Chemotherapy]] | [[Category:Chemotherapy]] | ||
| + | [[Category:Neutral chemotherapy]] | ||
[[Category:Enzymes]] | [[Category:Enzymes]] | ||
[[Category:Acute lymphocytic leukemia medications]] | [[Category:Acute lymphocytic leukemia medications]] | ||
Revision as of 20:32, 23 April 2017
This medication was discontinued by the manufacturer in December 2012, and is now essentially out of stock. Alternatives include Pegaspargase (Oncaspar) or Asparaginase Erwinia chrysanthemi (Erwinaze).
General information
Class/mechanism: Depletes plasma asparagine, selectively killing leukemic cells which are unable to synthesize asparagine due to a lack of asparagine synthetase.[1][2]
Route: IV, IM
Extravasation: neutral
For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, Medscape, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]
Diseases for which it is used
Patient drug information
- Asparaginase (Elspar) patient drug information (Chemocare)[3]
- Asparaginase (Elspar) patient drug information (UpToDate)[4]
Also known as
Asparaginasa, Asparaginase Medac, Chephacardin, Colaspase, Crasnitin, Crisantaspase, Elspar, Erwina Asparaginas, Erwinase, Erwinaze, Erwinia, Erwiniase, Kidrolase, L-ASP, L-Asparaginasa Filaxis, Laspar, L Asparaginasa, L Asparaginase, L Asparaginasum, Leucoginase, Leunase, Paronal