Difference between revisions of "Lenvatinib (Lenvima)"

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==Diseases for which it is used==
 
==Diseases for which it is used==
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*[[Renal cancer]]
 
*[[Thyroid cancer]]
 
*[[Thyroid cancer]]
  
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==History of changes in FDA indication==
 
==History of changes in FDA indication==
*2/13/2015: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm434347.htm FDA approved] "for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory [[Thyroid_cancer|differentiated thyroid cancer]]."
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*2/13/2015: [http://www.fda.gov/Drugs/InformationOnDrugs/ApprovedDrugs/ucm434347.htm FDA approved] for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory [[Thyroid_cancer|differentiated thyroid cancer]].
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*5/13/2016: FDA approved in combination with [[Everolimus (Afinitor)|everolimus]], for the treatment of advanced [[Renal cancer|renal cell carcinoma]] following one prior [[:Category:VEGF_inhibitors|anti-angiogenic therapy]].
  
 
==Also known as==
 
==Also known as==
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[[Category:RET inhibitors]]
 
[[Category:RET inhibitors]]
  
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[[Category:Renal cancer medications]]
 
[[Category:Thyroid cancer medications]]
 
[[Category:Thyroid cancer medications]]
 
[[Category:Drugs FDA approved in 2015]]
 
[[Category:Drugs FDA approved in 2015]]

Revision as of 01:22, 14 May 2016

General information

Class/mechanism: Tyrosine kinase inhibitor of multiple receptor tyrosine kinases (RTKs), including: vascular endothelial growth factor (VEGF) receptors VEGFR1 (FLT1), VEGFR2 (KDR), and VEGFR3 (FLT4); fibroblast growth factor (FGF) receptors FGFR1, FGFR2, FGFR3, and FGFR4; platelet derived growth factor receptor alpha (PDGFRα), KIT, and RET. Inhibition of these receptor tyrosine kinases interferes with cancer cells' proliferation and pathogenic angiogenesis.[1][2][3]
Route: PO
Extravasation: n/a

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the package insert.[1]

Diseases for which it is used

Patient drug information

History of changes in FDA indication

Also known as

E7080

References