Class/mechanism: Radioactive pharmaceutical agent (radium-223) that mimics some biologic behaviors of calcium and is incorporated into areas with increased bone turnover, such as bone metastases, by forming complexes with hydroxyapatite. Radium-223 emits alpha radiation at the site of bone metastases, which causes double-strand DNA breaks in nearby cells. The limited penetration of alpha radiation (<100 micrometers/uM, <10 cell diameters) is believed to limit the risk of adverse side effects. Radium-223's half-life is 11.4 days. Its specific activity is 1.9 MBq (51.4 microcurie)/ng; molecular weight of 223RaCl2: 293.9 g/mol.
Extravasation: no information
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Diseases for which it is used
Patient drug information
- Radium-223 (Xofigo) patient drug information (Chemocare)
- Brief patient counseling information can be found in the Radium-223 (Xofigo) package insert
History of changes in FDA indication
- 5/15/2013: FDA approved "for the treatment of patients with castration-resistant prostate cancer, symptomatic bone metastases and no known visceral metastatic disease."
Also known as
- Generic names: Ra-223, Radium Ra 223 dichloride, Radium-223 chloride
- Brand names: Alpharadin, Xofigo