Protamine sulfate (USP)

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General information

Class/mechanism: Heparin antagonist; protamine sulfate is a weak anticoagulant that forms a stable salt with heparin, after which the anticoagulant effect of both drugs is negated.[1][2][3]
Route: IV
Extravasation: no information

For conciseness and simplicity, currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.[1]

Patient drug information


  1. 1.0 1.1 Protamine sulfate package insert
  2. Protamine sulfate package insert (locally hosted backup)
  3. University of Michigan Health System Anticoagulation Reversal
  4. Protamine sulfate patient drug information (UpToDate)