Lutetium Lu 177 vipivotide tetraxetan (Pluvicto)
Class/mechanism: Radioligand therapeutic agent. The radionucleotide lutetium-177 is linked to vipivotide tetraxetan, which binds to PSMA (prostate-specific membrane antigen), a transmembrane protein that is expressed in prostate cancer. Binding of lutetium Lu 177 vipivotide tetraxetan to PSMA-positive cells results in delivery of beta-minus radiation, resulting in DNA damage and cell death. Lutetium 177's half-life is 6.647 days.
Extravasation: no information
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Diseases for which it is used
Patient drug information
History of changes in FDA indication
- 3/23/2022: FDA approved "for the treatment of adult patients with prostate-specific membrane antigen (PSMA)-positive metastatic castration-resistant prostate cancer (mCRPC) who have been treated with androgen receptor (AR) pathway inhibition and taxane-based chemotherapy." (Based on VISION)
- VISION: Sartor O, de Bono J, Chi KN, Fizazi K, Herrmann K, Rahbar K, Tagawa ST, Nordquist LT, Vaishampayan N, El-Haddad G, Park CH, Beer TM, Armour A, Pérez-Contreras WJ, DeSilvio M, Kpamegan E, Gericke G, Messmann RA, Morris MJ, Krause BJ; VISION Investigators. Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. N Engl J Med. 2021 Sep 16;385(12):1091-1103. Epub 2021 Jun 23. link to original article link to PMC article PubMed NCT03511664
History of changes in EMA indication
Also known as
- Generic names: Lutetium-177-PSMA-617, Lutetium PSMA