Oblimersen (Genasense)
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Mechanism of action
From the NCI Drug Dictionary: The sodium salt of a phosphorothioate antisense oligonucleotide targeted to the initiation codon region of mRNA for the anti-apoptotic gene Bcl-2. Oblimersen inhibits Bcl-2 mRNA translation, which may result in decreased expression of the Bcl-2 protein and tumor cell apoptosis. This agent may enhance the efficacy of standard cytotoxic chemotherapy.
Also known as
- Code name: G-3139
- Brand name: Genasense