Lestaurtinib (CEP-701)

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Mechanism of action

From the NCI Drug Dictionary: An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3.

Also known as

  • Code name: CEP-701