Erdheim-Chester disease
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3 regimens on this page
4 variants on this page
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Erdheim-Chester disease (ECD)
Vemurafenib (Zelboraf)
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Regimen
Pilot, <20 patients
Patients enrolled all had BRAF V600E mutation. This is the dose after de-escalation after the first four patients had excess adverse events.
- Vemurafenib (Zelboraf) 480 mg PO BID
Given until progression of disease or unacceptable toxicity
References
- Haroche J, Cohen-Aubart F, Emile JF, Maksud P, Drier A, Tolédano D, Barete S, Charlotte F, Cluzel P, Donadieu J, Benameur N, Grenier PA, Besnard S, Ory JP, Lifermann F, Idbaih A, Granel B, Graffin B, Hervier B, Arnaud L, Amoura Z. Reproducible and Sustained Efficacy of Targeted Therapy With Vemurafenib in Patients With BRAFV600E-Mutated Erdheim-Chester Disease. J Clin Oncol. 2014 Nov 24. [Epub ahead of print] link to original article contains verified protocol PubMed