Palbociclib (Ibrance)
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Mechanism of action
Orally bioavailable cyclin-dependent kinase 4/6 inhibitor.
Preliminary data
- Vaughn DJ, Hwang W, Lal P, Rosen MA, Gallagher M, O'Dwyer PJ. Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors. Cancer. 2014 Dec 18. [Epub ahead of print] link to original article PubMed