Cytarabine liposomal (DepoCyt)

General information

Class/mechanism: Pyrimidine analog, mimics cytosine. Converted intracellularly into cytarabine-5-triphosphate (ara-CTP). Exact mechanism of action not known; believed to inhibit DNA polymerase, incorporate into DNA and RNA, and kill cells undergoing DNA synthesis (S-phase) and sometimes block cells from progressing from the G1 phase to the S-phase.
Route: IT
Extravasation: irritant

• "In-line filters must not be used when administering DepoCyt."

For conciseness and simplicity, HemOnc.org currently will focus on treatment regimens and not list information such as: renal/hepatic dose adjustments, metabolism (including CYP450), excretion, monitoring parameters (although this will be considered for checklists), or manufacturer. Instead, for the most current information, please refer to your preferred pharmacopeias such as Micromedex, Lexicomp, UpToDate (courtesy of Lexicomp), or the prescribing information.

Diseases for which it is used

• CNS leukemia
• CNS lymphoma

Patient drug information

• Cytarabine liposomal (DepoCyt) package insert
• Cytarabine liposomal (DepoCyt) patient drug information (Chemocare)
• Cytarabine liposomal (DepoCyt) patient drug information (UpToDate)

History of changes in FDA indication

• 4/1/1999: Initial accelerated approval for intrathecal treatment of lymphomatous meningitis.
  • 4/19/2007: Converted to regular approval.
• 8/11/2011 (oldest label available at Drugs@FDA): indicated for the intrathecal treatment of lymphomatous meningitis.

Also known as

• Generic name: Liposomal Ara-C
• Brand name: DepoCyt